9 Retinal Development Flashcards
Optic Pits become optic ____. Which are made up of neural ectoderm
Vesicles
What’s made first, the optic vesicle or optic cup?
Vesicle
As the optic cup folds in on itself, the “back” of the cup comes into contact with the “front”. What orientation do they come together to form?
Apex to apex relationship
What’s the small space left over by formation of optic cup?
What does this space become eventually as layers connect together?
Intraretinal space
Potential space
What’s the most posterior reference of the optic cup for outer and inner layer?
RPE; Neural retina
The outer later of optic cup is ______ epithelium while the inner layer is ____ epithelium
PIGMENTED CILIARY
NON-pigmented
What’s the most anterior reference of the optic cup for outer and inner layer?
Outer=Anterior Iris Epithelium
Inner= POSTERIOR Iris Epithelium
Regarding the RPE: when does the pigmentation of the retinal epithelium occur? Approx. what week?
Week 3 or 4
Regarding the RPE: the earliest pigmentation is evident in the _______
Embryo
The neural retina will subdivide into two zones around weeks _ to _:
Outer area= ________ zone
Inner area=________ zone
4-6 weeks
Germinating zone
Marginal zone (of HIS)
By week __ the photoreceptors are aligned on the outer side of the inner layer of optic cup and junctions between them form ___________
12
External limiting membrane
What are the LAST cells of neural retina to differentiate?? What month does it occur
PHOTORECEPTOR cells
5th month
What differentiates first; cones or rods? During what month does this happen?
Cones first
Rods second
7th month
Step 1 of accessory retinal development:
The horizontal, bipolar, amacrine, and Muller cells are developing in the ____ nuclear layer
Inner
Step 2 of accessory retinal cell development:
Fibers of the _____ cells appear and extend to basal lamina, forming primitive internal limiting membrane
MULLER
