9 Retinal Development Flashcards
Optic Pits become optic ____. Which are made up of neural ectoderm
Vesicles
What’s made first, the optic vesicle or optic cup?
Vesicle
As the optic cup folds in on itself, the “back” of the cup comes into contact with the “front”. What orientation do they come together to form?
Apex to apex relationship
What’s the small space left over by formation of optic cup?
What does this space become eventually as layers connect together?
Intraretinal space
Potential space
What’s the most posterior reference of the optic cup for outer and inner layer?
RPE; Neural retina
The outer later of optic cup is ______ epithelium while the inner layer is ____ epithelium
PIGMENTED CILIARY
NON-pigmented
What’s the most anterior reference of the optic cup for outer and inner layer?
Outer=Anterior Iris Epithelium
Inner= POSTERIOR Iris Epithelium
Regarding the RPE: when does the pigmentation of the retinal epithelium occur? Approx. what week?
Week 3 or 4
Regarding the RPE: the earliest pigmentation is evident in the _______
Embryo
The neural retina will subdivide into two zones around weeks _ to _:
Outer area= ________ zone
Inner area=________ zone
4-6 weeks
Germinating zone
Marginal zone (of HIS)
By week __ the photoreceptors are aligned on the outer side of the inner layer of optic cup and junctions between them form ___________
12
External limiting membrane
What are the LAST cells of neural retina to differentiate?? What month does it occur
PHOTORECEPTOR cells
5th month
What differentiates first; cones or rods? During what month does this happen?
Cones first
Rods second
7th month
Step 1 of accessory retinal development:
The horizontal, bipolar, amacrine, and Muller cells are developing in the ____ nuclear layer
Inner
Step 2 of accessory retinal cell development:
Fibers of the _____ cells appear and extend to basal lamina, forming primitive internal limiting membrane
MULLER
Step 3 of accessory retinal cell development:
The _____ cell provides support for cell development, and act as traffic cops for axonal fiber growth
Muller
Step _ of retinal layer development:
Synaptic complexes appear same time as plexiform..with the ____ plexiform preceding the ___ layer
1
Inner
Outer
Step _ of retinal layer development:
_____pedicles develop before ___ spherules
2
Cone
Rod
Step _ of retinal layer development:
Photoreceptor synapses with _____ cells established way before outer segments completed
3
Bipolar
What line of deviation is caused by the central retina developing before the peripheral?
Horizontal Raphe
By month _ there is NO further mitosis in eye. Retinal growth continues because of what three things?
6
Cell differentiation
Growth
Maturation
In the _ month, cones begin to differentiate and foveal development occurs
6th
Displacement to form the depression
Migration of photoreceptors toward the center, which increases cone packing
Maturation of photoreceptors
What are these 3 steps for??
Foveal development
The foveal depression continues to deepen until about age __ months after birth as cells continue to move toward the macular periphery
15 months
Year 3 months old baby!!
