4 RPE

Question 1

List the layers of the retina in the order for which light passes through to reach the RPE

Answer 1

Inner plexiform Layer
Inner nuclear 
Outer plexiform
Outer nuclear 
Inner segments 
Outer segments
Retinal Pigmented Epithelium (RPE)

Question 2

What is the outermost layer of the retina?

Answer 2

Retinal Pigmented Epithelium

It’s basically a barrier between choroid (vascular layer) and retina

Question 3

Is there RPE at the optic nerve?

Answer 3

NO

Question 4

From the sclera to the vitreous, your going in a ____ direction; towards the vitreous.

The opposite way, vitreous to the sclera, is the _______ direction

Answer 4

Vitreed

Sclerad

Question 5

______ = away from center eye

______= towards center of eye

Answer 5

Outer = away from center eye

Inner = towards center of eye

Question 6

How many RPE cells are there? Where is the cell density the greatest?

Where does the RPE face towards?

Answer 6

4-6 million cells

Fovea! (5,000 cells/mm2)
Because more photoreceptors and needs to get rid of the waste

Faces apex of photoreceptors

Question 7

Out of the 11 million Americans with some form of AMD, what percent of those have Wet AMD?

Answer 7

10%

Question 8

Early in the morning, ____ discs are shed

In the evening, the ____ discs are shed

During the day, you use your _____ mostly

During nighttime, you’re using your ___ mostly

Answer 8

ROD

CONE

Cones=daytime vision (best acuity)

Rods= NIGHT vision

Question 9

With age related macular degeneration, there’s a buildup of fluid (blood, proteins etc) in the _____ layer. The ____ malfunctions and effects the ability of nutrients to get in, and waste to get out.

You will see ______ behind the RPE.

Answer 9

Bruch’s

RPE

Neovascularization

Question 10

What’s used to stop growth in wet macular degeneration?

Answer 10

VEGF inhibitors!!

Vascular endothelial growth factor

Question 11

What test could you use to see if your patient has AMD?

Answer 11

Amsler grid

Question 12

What fills the subretinal space between the RPE and PRs?

Answer 12

Interphotoreceptor matrix

Very strong, NO JUNCTIONS. Controls trafficking of nutrients

Question 13

What in the apical membrane helps keep fluid out of the retina? Regulates fluxes to keep sensory retina adhered to RPE

Answer 13

Na+/K+ ATPase pumps!!

Question 14

What RPE lateral membrane specialization prevents leaks? They are tight junctions between non-fenestrated endothelial cells of retinal capillaries

Answer 14

Zonula Occludens