9 - Labour and Delivery Flashcards
What happens to progesterone and why at the onset of labour?
Progesterone is withdrawn as progesterone prevents contractions
What occurs in the foetal adrenals at the onset of labour?
Foetal adrenals produce more DHEAs which is converted by the placenta to oestrogen
What is the role of oestrogen in the onset of labour?
Oestrogen promotes the release of prostaglandins from the decidua and foetal membranes
What are the two types of prostaglandin?
E2 and F2a
What do PG do?
Promote cervical ripening
Stimulate contractions
How does prostaglandin stimulate contractions?
Acts directly on the myometrium and increases the expression of oxytocin receptors
What is the difference between F and E prostaglandins?
F - contractant - release stimulated by oestrogen
E and I - relaxants - release stimulated by progesterone
What is ripening of he cervix?
Increase in distensibility
Collagen conc decreases and is replaced by amorphous substance
What changes on the myometrium does prostaglandins induce?
Cell to cell adhesion
Increase levels of oxytocin
What is the function of oxytocin in the myometrium?
Attach to receptors
Stimulate contractions - top downwards
What is the ferguson reflex?
foetus contacts baroreceptors in the cervix
stimulates and sends impulse to brain
Oxytocin released
Ocytocin binds to receptors in the myometrium and causes contraction
Baby pushes further into the cervix so another contraction is stimulated
What are the signs of labour?
Release of the mucous plug which seals the opening of the cervix
Rupture of membranes - breaking of the waters
Painful contractions - Last longer than 40 seconds (in labour)
How do you diagnose labour?
Progressive cervical dilation
Regular, painful uterine contractions - lasting for 40 seconds or longer
The show
Backache
What occurs in the first stage of labour?
0-10cm cervical dilation
rate of more than 1cm/hour
What are braxton hicks contractions?
Painful, rhythmic contractions occurring every 2-3minutes