9- Granulomatous disease

Question 1

Granulomatous disease is what form of inflammation

Answer 1

Chronic inflammation

Question 2

If neutrophils are involved in predominant in granulomatous disease what is it called?

Answer 2

Pyo-granulomatous

Question 3

Name a bacteria that causes granulomatous disease

Answer 3

Rhodococcus equi
Mycobacterium spp.
Actinobacillus spp.
Burkholderia mallei
Brucella spp.

Question 4

Describe the mechanism of Rhodococcus equi in causing granulomatous disease

Answer 4

Lysis of monocytes-macrophage system
Bacteria proliferate within macrophages (vapA gene- allowing survival)
Inhibits phagosome- lysosome fusion
Survival and replication

Question 5

What 2 disease are seen with mycobacterium spp

Answer 5

Johnes disease - mycobacterium avium paratuberculosis

Bovine TB - Mycobacterium bovis

Question 6

What condition does actinobacillus lignieresii cause

Answer 6

Wooden tongue

Question 7

Brucella spp. are transmitted via what route

Answer 7

Contact with inf. tissue, secretions or excretions

Question 8

T/F fungi can be degraded and removed by acute inflammation

Answer 8

False- causes a chronic granulomatous inflammation
Via virulence factors

Question 9

which cells are predominant in granulomatous disease

Answer 9

macrophages
epithelioid macrophages- are activated macrophages
multinucleated giant cells

Question 10

what can cause granulomatous disease

Answer 10

microbial agents
autoimmune disease
foreign bodies
other idiopathic conditions

Question 11

describe burkholderia mallei

Answer 11

glanders
is a zoonotic disease of donkeys, horses and mules
causes cutaneous nasal and pulmonary lesions
is a notifiable disease in the UK