9. Func Of Liver 1 Flashcards
1
Q
Name 5 cell (types) of liver
A
1 Hepatocytes (60%) 2 Kupffer cells (30%) liver macrophages 3 (Hepatic) stellate/(type of Ito cells)-vit A storage 4 Endothelial cells 5 Biliary (bile duct) epithelium
2
Q
Drug metabolism in liver
Phase 1
Phase 2
Phase 3
A
1 oxidation/reduction/hydrolysis
2 conjugation (attach ionised group like methyl, acetyl,glutathione) >water soluble for excretion
3. Drug eliminated by ATPase pumps
3
Q
Describe aa synthesis in liver via (-/-/-/-/-/-/-/-/-/-/-/-/-/-)
- General reaction
- Important reaction
A
Transamination 1. General reaction: Alpha-ketoacid=alpha-aa w transamine/aminotransferase enzyme 2. Glutamic acid+pyruvic acid>a ketaglutamic acid+ALANINE Via alanine transaminase-ALT
4
Q
GGT
What it is
What it does
Made by
A
.
5
Q
Describe aa metabolism In liver via oxidative deamination
A
.?
6
Q
Liver synthesise proteins such as (8 types)
Include roles
A
.
7
Q
Liver func:
Ammonia made from
Ammonia excreted how?
A
.
8
Q
Carb metabolism in liver
A
.
9
Q
Bile: 1 stored by ? & secreted via ? 2 secretion stimulated by ? 3 made up of 2 parts (describe) 4 role
A
.
10
Q
- How bilirubin made
2 how is it excreted
A
.
11
Q
Liver stores
(7) substances
A
.
12
Q
Lipid metabolism in liver
A
.
13
Q
Alcohol metabolism in liver
A
.
