9- Diseases of the Prostate Flashcards
What is the function of PSA?
Cleave semenogelin liquefying the coagulum and releasing sperm
What marker is used to detect prostatic cancer?
Serum PSA levels [Free vs. Total PSA]
PSA can be falsely elevated in what conditions?
Post-cytoscopy
Age
BPH
Prostatitis
Significance of PSA as a marker for Prostate cancer
Used to detect prostatic cancer and used to monitor response to therapy
Free vs. Total PSA levels in BPH and Prostatic cancer
↓ Free:Total Cancer
↑ Free:Total BPH
What secretes PSA?
Prostate epithelial cells
What organisms cause acute bacterial prostatitis?
- E. coli
- Gram -ve rods
- Enterococci
- Staphylococci
What factors contributes to chronic bacterial prostatitis?
Poor antibiotic penetration of prostate contributes to chronicity of this condition
What are the signs and symptoms of Chronic bacterial prostatitis?
- Lower back pain
- Dysuria
- Perineal + Suprapubic discomfort
- Asymptomatic
What are the signs and symptoms of Acute bacterial prostatitis?
- Fever
- Chills
- Dysuria
- Exquistely tender prostate on exam
What is the most common form prostatitis?
Chronic abacterial prostatitis
What is the cause of chronic abacterial prostatitis?
Unknown etiology
What are the causes of Granulomatous prostatitis?
Infectious [TB/Fungal]
Noninfectious
What is a common cause of Granulomatous prostatitis?
Instillation of BCG for treatment of bladder cancer
What do non-specific granulomatous prostatitis represent?
A reaction to secretions from ruptured prostatic ducts and acini
