9/23- Renal Review 1- Pathology Flashcards
What are characteristics of Acute renal failure?
- Oliguria or anuria
- Increased BUN and creatinine
- Decreased GFR
- Injury of any compartment of the kidney can result in ARF
- Glomeruli
- Tubules/Interstitium
- Vessels
What are characteristics of Chronic renal failure?
Prolonged course
- Diminished reserve, GFR 50%
- Renal insufficiency, GFR 20-50%
- Chronic renal failure, GFR <20%
- End stage, GFR 5%
Systemic changes
What is seen here?
Chronic renal failure (Thyroid-like?)
What glomerular properties account for the very low urinary protein content or normal urine?
Charge barrier
- GBM negatively charged (Heparan sulphate)
- Podocyte and endothelium negatively charged (Sialoproteins)
Size barrier
- Porous GBM
- Slit diaphragm
What are the arrows pointing at?
Slit diaphragms
What are the issues at play in nephrotic syndrome (mechanistic)?
Charge issues
- Increased matrix of GBM (with diabetes or electron dense deposits with membranous glomerulopathy)
Podocyte changes
- Effaced foot processes (minimal change disease, focal segmental glomerulosclerosis)
What are the issues at play in nephritic syndrome (mechanistic)?
Disruption of capillary loops with spillage of protein and red cells
- Active urinary sediment Spilled proteins may incite crescent formation
What are histologic alterations of glomerular injury?
Hypercellularity
- Mesangial cells
- Endothelial cells
- Leukocyte infiltrates
- Crescents
Basement membrane thickening
- Immune complex deposition
- Membrane reduplication
- Increased matrix
Hyalinosis and Sclerosis
- Extracellular insudated plasma proteins
- Sclerosis contains collagen
- FSGS
What is seen here?
Normal glomerulus
What is seen here?
Hypercellular mesangium
- Still see open cap loops branching off
What is seen here (what disease does it indicate)?
IgA immune deposits in mesangium -> IgA Nephropathy
What is seen here (what disease does it indicate)?
IgA nephropathy
- Mesangial immune deposits
What is seen here (what disease does it indicate)?
IgA nephropathy
- Variable, mesangial hypercellularity
- Ranging to crescents
What is seen here?
Endocapillary and mesangial proliferation
- Can’t see cap loops
- Mesangium all blurred together
- Looks like catcher’s mitt
Membranoproliferative GN
IgA nephropathy with skin rash is what?
Henoch-Schonlein purpura
What is seen here?
Leukocyte infiltration
What is seen here?
Crescent formation
What is Crescent Glomerulonephritis/RPGN?
- Variant of acute nephritis
- Three groups:
1. Immune complex GN
- SLE
- Post-infectious
- IgA/HSP
2. Anti-GBM GN
3. Pauci-immune (ANCA)
- IF/EM will distinguish
What is the #1 cause of crescentic GN?
ANCA (Pauci-immune) GN
What is Pauci-immune GN?
(ANCA GN)
- No 1 cause of crescentic GN
- May be renal limited or systemic (Wegener’s, Churg-Strauss, Microscopic polyangiitis)
- 80% of pts have circulating ANCA
- ANCA is pathogenic (mouse studies)
What is seen here?
Increased matrix
What is seen here? Where are deposits?
What diseases are indicated?
Left: granular/globular epimembranous distribution (?)
- Seen in Membranous GN (or lupus or 2’…)
Right: linear epimembranous distribution (?)
- Seen in Anti-GBM