9/16- Chronic Kidney Disease (CKD) Flashcards
What is CKD (vs. AKD)?
- Not reversible (in contrast to AKD)
- Progressive even after original disease causing kidney damage is treated
- Associated with other illnesses: heart disease, HTN
What are the stages of CKD?
What is the model explaining progressive kidney failure?
Remnant kidney model
Primary renal injury -> loss of nephrons
- > Hyperfiltration of remaining nephrons
- > Increased glomerular pressure
- > Mesangial cell and endothelial cell injury
- > Mesangial cell and matrix expansion
- > Focal sclerosis
- > Loss of nephrons AND REPEAT
Key is to stop the pressure
What is normal GFR?
125 mL/min
What is normal Na?
140 mM
Angiotensin II acts on the ____ (afferent/efferent) arteriole
Angiotensin II acts on the efferent arteriole
- -> constriction
- Also have increased glomerular pressure
Important
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What is the pathogenesis of CKD (proteinuria and glomerulosclerosis)?
(Subtotal nephrectomy in rat is good experimental model) Reduction in functioning nephrons increases systemic hypertension and single nephron glomerular filtration rate (SNGFR)
- Systemic hypertension accelerates renal arteriolar damage, contributes to micro aneurysm formation
- Increased glomerular pressure raises SNGFR, but enlarges glom tuft, damages epithelial cells, causing mesangial hyaline deposits, and glomerular thrombi
What is the pathogenesis of CKD (glomerular and tubulointerstitial damage)?
Glomerular sclerosis
- Glomerular focal sclerosis, and hyalinosis
- Tubules atrophy
- Chronic interstitial inflammation
Tubular-interstitial fibrosis end result
Gross changes seen in CKD?
- Bilateral contracted kidneys
- Thin renal cortex
- Multiple cysts (acquired cystic disease)
What are some interventions to slow progression of CKD?
Control glomerular pressure
- Low protein diet
- BP control
- ACEI and ARBs
(stop Ang II increase in glomerular pressure)
What kind of diet is ideal for slowing progression of CKD? Details?
Low protein diet (0.5 g/kg body mass)
- Loss of renal function limits ability to match intake and output
- Renal diet may conflict with pt’s previous dietary practices (e.g. diabetic diets)
- 0.5 g/kg body mass…
- High biological grade protein
- Problems with compliance, food choices, blood sugar control, malnutrition
What are the effects of angiotensin II?
- Vasoconstriction
- Aldosterone production
- > Sodium retention
ACEI and ARB may cause what in diabetics?
Bump in creatinine
What are results of kidney failure in terms of:
- Toxin accumulation
- Abnormal electrolyte levels
- Endocrine system
Toxin accumulation
- High BUN and creatinine
Abnormal electrolyte levels
- Fluid retention, CHF…
- Hyponatremia
- Hyper/hypo-kalemia
- Acidosis
- Hyperphosphatemia
Endocrine system
- Low Vit D -> hypocalcemia (no activation of Vit D 25 to 1,25)
- Anemia (decreased EPO production)
- Hypoglycemia (failure to metabolize insulin)