8A - Mutations and Gene Expression Flashcards
1
Q
Mutation
A
- any change to the nucleotide sequence of DNA or chromosome
2
Q
Mutagenic agent
A
- any factors which increase the likelihood of mutations e.g. radiation, chemicals and some viruses
3
Q
Substitution
A
- a mutation in which one or more bases are swapped for another
4
Q
Deletion
A
- a mutation in which one or more bases are removed
5
Q
Addition
A
- a mutation in which one or more bases are added
6
Q
Duplication
A
- a mutation in which one or more bases are repeated
7
Q
Translocation
A
- a mutation in which a sequences of bases is moved from one location on the genome to another
- could be on the same chromosome or different chromosome
8
Q
Frameshift mutation
A
- Mutations that change the number of bases in the DNA code, meaning the triplet code is ‘read’ in a different way
9
Q
Mutations and amino acids
A
- Mutations can sometimes code for the same amino acids(e.g. substitution) due to the degenerate nature of the triplet code, however others such as addition or deletion cause different amino acids to be coded for
10
Q
Mutations and proteins
A
- If mutation changes the amino acid coded for, this will alter the primary structure, and consequently the ‘folding’ which occurs in forming the secondary and tertiary structure
- changes the location of bonds between the amino acids and can change the shape, producing a ‘non functional’ protein
11
Q
Impact of mutagenic agents
A
- Acting as a base, altering bases, changing the structure of DNA
12
Q
Acting as a base
A
- Some mutagenic agents are able to substitute for a base, changing the DNA sequence
13
Q
Altering bases
A
- Some mutagenic agents can alter or delete bases
14
Q
Changing structure of DNA
A
- Some mutagenic agents can change the structure of DNA, causing problems during replication
15
Q
Acquired mutations
A
- Mutations that occur in individual cells after fertilisation
16
Q
Tumour
A
- A mass of abnormal cells, brought on by a mutation causing uncontrolled cell division
17
Q
Cancers
A
- Tumours that invade and destroy surrounding tissue
18
Q
Tumour suppressor genes
A
- Code for a protein which stops cells dividing or causes them to self-destruct(apoptosis), regulating the rate of cellular division
19
Q
Mutated tumour suppressor genes
A
- Mutations prevent the coding of the TSG. The protein is not coded for and cellular division is not regulated. The rate of division increases and tumours form
20
Q
Proto-oncogenes
A
- Stimulate cell division by producing proteins that make cells divide
21
Q
Oncogenes
A
- Mutated proto-oncogenes, causing the protein to be coded for multiple times, hence rapidly increasing the rate of division and forming tumours
22
Q
Malignant tumours
A
- cancers which grow rapidly, invade, and destroy surrounding body tissue
- cells can break off and metastasise to elsewhere in the body using the bloodstream of lymphatic system