850-IP 8 Delfin_Vasodilators/Vasopressors/PositiveInotropes Flashcards
Positive Inotropes
– ⍺1-agonists
• ⍺1-adrenergic receptor agonists
– β1-agonists
• β1-adrenergic receptor agonists
• PDE3 inhibitors
What is inotropy?
Altered contractility
What is lusitropy?
Altered relaxation
What is chronotropy?
Altered contraction rate (SA node conduction)
What is dromotropy?
Altered AV node conduction
Beta-blockers are the best treatment option for both chronic and acute-decompensated heart failure?
A. True
B. False
A. True
B. False
The primary neurotransmitter that activates the adrenergic system is\_\_\_\_\_\_\_\_\_. A. Monoamine oxidase B. Dopamine C. Dobutamine D. Norepinephrine
A. Monoamine oxidase
B. Dopamine
C. Dobutamine
D. Norepinephrine
Adrenergic receptors mediate the
reaction to sympathetic nervous
system activation
• Primary physiological purpose is to react to epinephrine (adrenaline) and norepinephrine (noradrenaline)
• Norepinephrine is the primary transmitter for the adrenergic system
• Effects on different tissues and organs vary
– Dependentonadrenergic receptor subtype(s) in tissue
Adrenergic receptor subtype
⍺1 Main localization
Smooth muscle (vascular, visceral)
Adrenergic receptor subtype
⍺2 Main localization
Pre-synaptic nerve endings, pancreas, platelets, salivary glands
Adrenergic receptor subtype
β1 Main localization
Heart, kidneys
Adrenergic receptor subtype
β2 Main localization
Smooth muscles (visceral), bronchioles, liver, skeletal muscle
Adrenergic receptor subtype
β3 Main localization
Adipose, bladder
