850- Bleske drugs handout

Question 1

Vaughan-Williams class of agents

IA

Answer 1

Agents:
1. Quinidine
2. Procainamide
(Disopyramide)

Tissue: Atrial and Ventricles

• These drugs block open or inactivated sodium
• Class IA drugs slow Phase 0 depolarization, prolong action potential, and slow conduction

Question 2

Vaughan-Williams class of agents

IB

Answer 2

Agents:

1. Lidocaine
2. Phenytoin
3. Mexiletine

Tissue: Ventricle

Question 3

Vaughan-Williams class of agents

IC

Answer 3

Agents:

1. Propafenone
2. Flecainide

Tissue: Atrial, Ventricle, AV-node

Question 4

Vaughan-Williams class of agents

II

Answer 4

Agents:

1. Atenolol
2. Metoprolol
3. Propranolol, etc.

Tissue: SA node, AV-node, Ventricle

Question 5

Vaughan-Williams class of agents

III

Answer 5

Agents:

1. Amiodarone (AV nodes, Atrial, Ventricle)
2. Ibutilide (Atrial)
3. Dofetilide (Atrial, Ventricle)
4. Sotalol (Atrial, Ventricle)
5. Droneadrone (Atrial, Ventricle)

Question 6

Vaughan-Williams class of agents

IV

Answer 6

Agents:

1. Verapamil
2. Diltiazem

Tissue: SA and AV node

Question 7

Vaughan-Williams class of agents

V

Answer 7

Agents:

1. Adenosine (AV node)
2. Digoxin (SA and AV node)

Question 8

Other Atropine

Answer 8

SA and AV node (increase conduction)

Question 9

Adenosine

Answer 9

AV node (slows conduction)

Question 10

Magnesium

Answer 10

Ventricle tissue

Question 11

AA MOA: Slow conduction velocity of Action potential

Answer 11

1. Increase refractoriness (changes in effective refractory period and action potential duration)
2. Create a two way block in reentry circuit

Question 12

AA MOA: Change the slope of phase 4

Answer 12

1. Decrease (e.g. beta blockers) or increase automaticity (e.g. atropine epinephrine)

Question 13

AA MOA: Change the threshold potential or maximum diastolic potential

Answer 13

1. Decrease or increase automaticity