850- Bleske drugs handout part 2

Question 1

Antiarrhythmics: Impact on ECG

Class I (Na channel blocker)

Answer 1

1. Mechanism: 1c > 1a > 1b
2. ECG Effect:
   - 1a: increase QT, QRS, and PR
   - 1b: usually no change
   - 1c: increase PR and QRS

Question 2

Antiarrhythmics: Impact on ECG

Class II (beta blocker)

Answer 2

1. Mechanism: AV nodal blockade

2. ECG Effect: Decrease HR and Increase PR

Question 3

Antiarrhythmics: Impact on ECG

Class III (potassium blocker)

Answer 3

1. Mechanism: Slows repolarization

2. ECG Effect: Increase QT

Question 4

Antiarrhythmics: Impact on ECG

Class IV (calcium channel blocker)

Answer 4

1. Mechanism: AV nodal Blockade

2. ECG Effect: Decrease HR and Increase PR

Question 5

Must monitor QT interval for which patients on blank 1, blank 2, and blank 3. (Antiarrhythmic agents)

Answer 5

1. IA
2. IC
3. III

(Prevent Torsades Du Pointes)

Question 6

Need to monitor PR interval for blank 1, blank 2, and blank 3.

Answer 6

1. Class II
2. Amiodarone
3. Class IV AA

(Prevent AV block)

Question 7

Class: IA and IC
Tissue: Atrial, Ventricular

Effect & ECG???

Answer 7

1. Effect: Decrease AP conduction increase refractoriness - fast arrhythmias
2. ECG: Increase PR and increase QT

Question 8

Class: IB
Tissue: Ventricular

Effect & ECG???

Answer 8

1. Effect: Increase refractoriness - fast arrhythmias

2. ECG: no effects

Question 9

Class: II
Tissue: SA, AV nodes, Atrial and Ventricular

Effect & ECG???

Answer 9

1. Effect: Slow conduction through AV node, decrease heart rate - fast arrhythmias
2. ECG: Increase PR and decrease HR

Question 10

Class: III
Tissue: Atrial and Ventricular (some do not affect V tissue)

Effect & ECG???

Answer 10

1. Effect: Decrease AP conduction, increase refractoriness - fast arrhythmias
   - Amiodarone/Sotalol may slow AV conduction
2. ECG: Increase PR and increase QT

Question 11

Class: IV
Tissue: SA and AV nodes

Effect & ECG???

Answer 11

1. Effect: Slow conduction through AV node, decrease heart rate-fast arrhythmias
2. ECG: increase PR and decrease HR

Question 12

Class: V?
Tissue: AV node

Effect & ECG???

Answer 12

1. Effect: Slow conduction through AV node-fast arrhythmias

2. ECG: Increase PR and decrease HR

Question 13

Class: Atropine
Tissue: SA and AV node

Effect & ECG???

Answer 13

1. Effect: Increase conduction, increase HR-slow arrhythmias

2. ECG: Increase HR