8.2 Consciousness Flashcards
why can antihistamines cause drowsiness?
pathway of hypothalamus projecting histamine to cortex is blocked
why can anticholinergics cause drowsiness?
pathway of basal forebrain nuclei protecting Ach to cortex is blocked
what projects glutamate to cortex?
thalamus
reticular activating system
ascending excitatory neurones from reticular formation essential for maintenance of consciousness
feedback between cortex and reticular formation
positive feedback loop of excitatory signals
drawback of EEG
low spatial resolution so cant tell where a seizure comes from
phenomenon of neurones when deprived of sensory input e.g. seizure/sleep
fire synchronously
how does sleep help clear extracellular debris?
interstitial fluid moves around, clearing amyloid