8.1 Learning And Memory Mechanisms

Question 1

How is content-addressable memory produced?

Answer 1

Synpase is active as the same time as postsynaptic cell

Question 2

What is long term depression?

Answer 2

Form of Hebburn modification
Synapses weaken, giving preparer breadth of memory, helps tune memory

Question 3

What is anterograde amnesia?

Answer 3

New long term explicit memories can’t be formed

Question 4

What is post-tetanic potentiation

Answer 4

Transient increase prior to decay of LTP

Question 5

Where does post-tetanus potentiation occur?

Answer 5

Presynaptic terminal, not postsynaptic side

Question 6

How does tetanus toxin cause convulsions?

Answer 6

Blocks release of glycine from inhibitory neurons

Question 7

What frequencies cause activity in postsynaptic cells?

Answer 7

High frequency stim = lots of activity in postsyn. cell
Low frequency stim = our of phase activity btwn cell in postsynaptic and presynaptic terminals

Question 8

What is an example of a postsynaptic mechanism for LTP?

Answer 8

1. Glutamate excites AMPA, unblocking NMDA
2. Ca2+ enters NMDA receptors activating Ca2+ dependent kindness
3. These kinases phosphorylate AMPA receptors
4. Insertion of AMPA receptors into postsynaptic membrane while Ca2+ can enter via voltage gated4

Question 9

What are 3 methods of regulating protein synthesis?

Answer 9

1. Phosphorylation
2. Receptor sensitisation
3. Increased receptor number