8 - Transport in animals Flashcards

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1
Q

why do multicellular organisms need a transport system?

A
  • diffusion alone is too slow to meet the organism’s needs.
  • relatively high metabolic demand and rate.
  • small SA:V ratio, diffusion distance increases ad surface area for diffusion becomes relatively smaller..
  • SA:V ratio gets smaller as organisms get bigger.
  • waste products of metabolism need to be removed.
  • molecules like hormones and enzymes may be produced at one place but needed in another place.
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2
Q

common features of circulatory systems?

A
  • they have a liquid transport medium (blood) that circulates around the system.
  • vessels that carry the liquid transport medium.
  • pumping mechanism to move the liquid transport medium around the system
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3
Q

open circulatory system

A
  • few vessels to contain the blood. Blood isn’t contained in blood vessels all the time.
  • blood is pumped from heart straight to body cavity of the animal.
  • blood comes into direct contact with tissues/cells.
  • blood returns to heart through an open-ended vessel.
  • amount of blood flowing to a particular tissue cannot be controlled.

found in:

  • invertebrates
  • most insects
  • molluscs
  • in insects, open circulatory system transports nutrients and nitrogenous waste products.
  • oxygen is transported by the tracheal system.
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4
Q

closed circulatory system

A
  • blood is enclosed inside blood vessels.
  • blood does not come into direct contact with tissues/cells.
  • substances leave and enter body cells by diffusing through walls of blood vessels.
  • heart pumps blood around body and blood returns directly to the heart through blood vessels.
  • amount of blood flowing to a particular tissue can be controlled - by widening or narrowing blood vessels.
  • single closed circulatory systems:
    fish

double closed circulatory systems:
mammals

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5
Q

single closed circulatory system

A

fish
annelid worms

  • blood flows through heart once for each complete circulation of the body.

in fish, heart pumps blood to gills, then rest of body, then returns to heart in a single circuit.

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6
Q

double closed circulatory system

A

mammals

  • blood flows through heart twice for each complete circulation of the body.
  1. blood is pumped from heart to lungs (oxygen collected, CO2 unloaded)
  2. blood is pumped from heart to rest of body and returns to the heart.
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7
Q

elastin fibres

A
  • composed of elastin
  • can stretch and recoil
  • provides vessel walls with flexibility
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8
Q

smooth muscle

A
  • contracts or relaxes to change the size of the lumen.
  • contracts: constricts the blood vessel (lumen decreases in size).
  • relaxes: dilates the blood vessel (lumen increases in size).
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9
Q

collagen

A
  • provides structural support to maintain shape and volume of vessels.
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10
Q

Arteries and arterioles

A
  • arteries carry blood from heart to tissues in the body.
  • oxygenated blood (but pulmonary artery carries deoxygenated blood from heart to lungs).
  • elastic fibres for stretching and recoiling of artery helps to maintain high pressure.
  • folded endothelium allows artery to expand. Helps to maintain pressure.
  • smooth endothelium reduces resistance of blood flow.

Arterioles:

  • less elastic fibres in walls: little pulse surge.
  • more smooth muscles: arterioles contract/dilate to control flow of blood to individual organs.
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11
Q

Why is aorta biggest, has most elastin fibres, and collagen?

A
  • connecting directly to the heart, pressure is greatest here.
  • lots of elastic fibres to maintain the very high pressure, to ensure that the blood is pumped to all areas of the body.
  • lots of collagen to prevent bursting (due to very high pressure).
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12
Q

What is the trend of the different tissues in arteries with increasing distance from heart?

A

as distance from heart increases:

  • amount of elastin decreases
  • amount of smooth muscle increases and then decreases, but with there being more smooth muscle in arteriole than aorta.
  • amount of collagen decreases dramatically but then increases slightly.
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13
Q

capillaries

A
  • microscopic blood vessels
  • links arterioles with venules.
  • tiny lumen, red blood cells travel in single file.
  • substances are exchanged with tissues and blood through capillary walls.
  • 1 cell thick endothelium (short diffusion distance)

how are they adapted to their role:

  • lots of them, provides a very large surface area for diffusion of substances.
  • total cross sectional area of capillaries is greater than arterioles, so blood slows down when entering capillaries. Provides time for diffusion of substances.
  • 1 cell thick endothelium. Short diffusion distance.
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14
Q

Veins and venules

A
  • veins carry blood from body cells to heart.
  • deoxygenated blood (but pulmonary vein carries oxygenated blood from lungs to heart)
  • deoxygenated blood from capillaries, then venules, then larger veins, then inferior vena cava (lower body) and superior vena cava (head and upper body).
  • no pulse (surge lost from passing through narrow capillaries).
  • large blood reservoir (60% of blood volume at any one time)
  • low blood pressure: has valves to prevent backflow of blood
  • lots of collagen
  • little elastic fibres
  • wide lumen
  • smooth endothelium: reduces resistance of blood flow.

venules:

  • link capillaries with veins.
  • thin walls, little smooth muscle.
  • several venules join to form vein.
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15
Q

How is the deoxygenated blood in the veins moved back to the heart (low pressure)?

A
  • one way valves at intervals prevent backflow of blood.
  • many bigger veins run along active muscles such as arms and legs. When they contract, veins are squeezed, forcing blood towards heart. When they relax, valves help to prevent backflow.
  • Breathing movements and changes in pressure move blood in veins of chest and abdomen towards heart.
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16
Q

What is the trend of the different tissues in veins with increasing distance from heart?

A

As distance from heart increases:

  • amount of elastin decreases with no elastin in venules
  • amount of smooth muscle decreases with no smooth muscle in venules.
  • amount of collagen decreases slightly.
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17
Q

What is blood composed of?

A

55% plasma

45% erythrocytes, leucocytes, platelets

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18
Q

Functions of blood?

A
  • transport oxygen and CO2 to and from cells.
  • transport digested food from small intestine.
  • transport hormones
  • transport platelets to wounds
  • transport cells and antibodies in immune response.
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19
Q

What is tissue fluid?

A
  • composed of plasma leaked through gaps in capillary walls.
  • fluid that surrounds cells of tissues.
  • consists of no plasma proteins, very few white blood cells, no red blood cells, water, dissolved solutes.
  • responsible for exchange (cells take up oxygen and nutrients from tissue fluid and release metabolic waste CO2 into tissue fluid).

Why are red blood cells and most plasma proteins not in tissue fluid?
- they are too large to fit through the gaps in the capillary walls.

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20
Q

How is tissue fluid formed?

A
  • arterial end (start) has a high hydrostatic pressure.
  • oncotic pressure (plasma proteins remain in capillaries.) stays the same.
  • hydrostatic pressure is greater than oncotic pressure.
  • plasma is forced out of the capillary through gaps in the walls and forms tissue fluid.
  • venous end (end) now has a lower hydrostatic pressure than the oncotic pressure
  • oncotic pressure stays the same.
  • water potential is lower is lower in capillary.
  • moves moves back into capillaries by osmosis raising the hydrostatic pressure.
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21
Q

What is lymph? How is it formed?

A
  • not all tissue fluid returns to the capillaries.
  • 10% of tissue fluid drain into blind-ended lymph vessels, and is known as lymph
  • contains less oxygen and fewer nutrients than tissue fluid and plasma.
  • fatty acids (from small intestine).
  • white blood cells
  • water
  • dissolved solutes.
  • antibodies

Lymph drains back into capillaries as blood plasma via lymph vessels.

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22
Q

What are lymph nodes?

A
  • Along the lymph vessels, there are lymph nodes.
  • they produce lymphocytes
  • lymph nodes filter bacteria and foreign matter from the lymph (fluid). They are digested by phagocytes in the nodes.
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23
Q

Why do doctors check neck, armpits, stomach, groin of patients?

A
  • sites of some major lymph nodes.
  • enlarged lymph nodes:
    sign that the body is fighting off an invading pathogen.
24
Q

aorta

A
  • oxygenated blood

- heart to whole of body

25
Q

pulmonary artery

A
  • deoxygenated blood

- heart to lungs

26
Q

pulmonary vein

A
  • oxygenated blood

- lungs to heart

27
Q

inferior vena cava

A
  • deoxygenated from

- lower body to heart

28
Q

superior vena cava

A
  • deoxygenated blood

- upper body and head to heart

29
Q

tricuspid valve (right atrioventricular valve)

A

prevents backflow of blood to right atrium when blood is pumped from right ventricle to pulmonary artery

30
Q

bicuspid valve (left atrioventricular valve)

A

prevents backflow of blood to left atrium when blood is pumped from left ventricle to aorta.

31
Q

semi lunar valves

A
  • pulmonary artery
  • aorta

These are the vessels which blood goes through away from the heart.

prevents backflow of blood back to the heart when blood is pumped through pulmonary artery (deoxy to lungs) and aorta (oxy to around the body).

32
Q

Stages of blood movement in the heart?

A
  • deoxygenated blood enters right atrium through inferior and superior vena cava.
  • slight pressure build, tricuspid valve opens and blood passes to right ventricle.
  • when right atrium and ventricle are filled with blood, atrium contracts and all blood is forced into ventricle, stretching ventricle walls.
  • as right ventricle contracts, tricuspid valve closes (prevents backflow to atrium) and deoxygenated blood is pumped through semilunar valves into pulmonary artery to lungs.
  • semi lunar valves prevent backflow into the heart.
  • at the same time, oxygenated blood from lungs enters left atrium through pulmonary vein.
  • as pressure builds in atrium, bicuspid valve opens and left ventricle fills with blood.
  • When both atrium and ventricle are full, left atrium contracts, forcing all the oxygenated blood into ventricle.
  • As ventricle contracts, bicuspid valve closes (prevents backflow into atrium)
  • blood is pumped through semilunar valves into aorta, where the blood travels around the body.
33
Q

Why are the muscular walls of left side of heart greater than right?

A
  • right side pumps blood to only lungs, which is relatively close to heart, not a lot of resistance to overcome.
  • left side pumps blood to the whole body, so the blood needs to be pumped at a much greater pressure, to overcome the resistance of the vessels of the whole body.
  • left side has thicker walls to maintain the high pressure.
34
Q

Septum

A

Inner dividing wall of the heart, which prevents the mixing of deoxygenated and oxygenated blood.

35
Q

What is diastole?

A
  • heart relaxes
  • atria and then ventricles will with blood.
  • pressure in the heart increases.
  • minimal blood pressure in arteries.
36
Q

What is systole?

A
  • atria contract
  • followed by ventricles contracting.
  • volume of heart decreases, pressure increases dramatically.
  • blood is forced out left side to whole body, right side to lungs.
  • maximal blood pressure in arteries.
37
Q

cardiac output equation

A

cardiac output = heart rate x stoke volume

38
Q

What is the cardiac muscle described as and why?

A
  • Myogenic

- can contract and relax without receiving signals from nerves.

39
Q

Heart action stages?

A
  • electrical impulses are generated by sinoatrial node (SAN) and travels along conducting fibres in the walls of atria.
  • causes left and right atria to contract at same time.
  • layer of non-conducting tissue prevents electrical impulses from SAN reaching the ventricles so that they don’t contract at the same time.
  • but, SAN excites the atrioventricular node (AVN) where it generates an electrical impulse on a slight delay (so that ventricles contract after atria after they have filled with blood).
  • electrical impulses travel along bundle of his, spreading to the purkyne fibres.
  • this causes the left and right ventricles to contract at the same time, from the bottom up.
40
Q

What does an electrocardiogram (ECG) record?

A
  • the electrical activity of the heart
41
Q

tachycardia

A

when the heartbeat is very rapid, over 100bpm

42
Q

bradycardia

A

when the heartbeat is very slow, below 60bpm.

43
Q

ectopic heartbeat

A

extra heartbeats that are out of the normal rhythm.

44
Q

atrial fibrillation

A

abnormal rhythm of the heart.

45
Q

What is the equation for haemoglobin and oxygen?

A

haemoglobin + oxygen ⇌ oxyhaemoglobin.

Hb + 4O2 ⇌ Hb(O2)4

REVERSIBLE

46
Q

How can haemoglobin carry oxygen?

A
  • Contains prosthetic haem groups which contain iron ions.
  • The iron ions provides affinity for oxygen.
  • each molecule can bind to four oxygen molecules (high affinity for oxygen).
  • oxygen binds to the iron ions, therefore haemoglobin can carry oxygen.
47
Q

Why is haemoglobin + oxygen reversible?

A
  • picks up oxygen from lungs and transports it to respiring cells, where the oxygen is released.
48
Q

How many oxygen molecules can one haemoglobin molecule bind to?

A

each haemoglobin molecule can bind to FOUR oxygen molecules.

49
Q

What is cooperative binding / positive cooperativity?

A
  • 1st oxygen molecule binds to haemoglobin.
  • haemoglobin molecule shape changes.
  • easier for next oxygen molecule to bind.
  • this is known as positive cooperativity
50
Q

Explain the oxygen dissociation curve

A
  • percentage saturation of haemoglobin with oxygen plotted against partial pressure of oxygen.
  • at low pO2, few haem groups are bound to oxygen, so percentage saturation of haemoglobin with oxygen is low.
  • at higher pO2, more haem groups are bound to oxygen, making it easier for more oxygen to be picked up. Percentage saturation is greater.
  • at very high pO2, haemoglobin becomes completely saturated (100%) as all the haem groups become bound too oxygen.
51
Q

Effect of CO2 on the oxygen dissociation curve? Importance?

A
  • bohr shift
  • as partial pressure of CO2 increases, oxygen dissociation curve shifts to the right.
  • at higher pCO2, oxygen unloads more readily to supply active tissues.

this is important:

  • in active tissues, pCO2 is high, haemoglobin unloads oxygen more quickly.
  • in lungs, pCO2 is low, oxygen binds to haemoglobin more easily.
52
Q

How does your body cope in low O2 environments such as high altitude?

A
  • pO2 is less
  • %saturation of haemoglobin with oxygen will decreases
  • body makes more red blood cells.
53
Q

Why is the oxygen dissociation curve s-shaped?

A
  • middle is very steep because it is very easy for the oxygen to join.
  • at very high pO2, Hb is more saturated and makes it harder for more molecules of O2 to join.
  • at low pO2, low levels of oxygen so harder to bind to haemoglobin.
54
Q

Describe the affinity for oxygen in fetal haemoglobin compared to adult haemoglobin? Why?

A
  • fetal haemoglobin has a higher affinity for oxygen than adult haemoglobin at the same partial pressure of oxygen.
  • fetus is completely dependent on its mother for oxygen supply.
  • higher affinity for oxygen of fetal haemoglobin means that oxygen transfers from maternal blood to fetal blood, when they move past each other.
  • if adult and fetal haemoglobin had the same affinity for oxygen, then little or no oxygen would be transferred to the fetal blood to supply the fetus.
55
Q

Stages of transporting CO2 in red blood cells?

A
  • carbon dioxide diffuses into red blood cells.
  • carbon dioxide reacts with water to produce carbonic acid. Catalysed by carbonic anhydrase.
  • carbonic acid dissociates to form H+ ions and hydrogen carbonate ions
  • increase in H+ ions causes oxyhaemoglobin to dissociate to haemoglobin and oxygen.
  • haemoglobin acts as a buffer and reacts with the H+ ions to produce haemoglobinic acid (HHb).
  • negatively charged hydrogen carbonate ions diffuse out of the cell.
  • negatively charged chloride ions diffuse into the cell to maintain electrochemical balance of the cell. Called the chloride shift.
  • When the red blood cells reach the lungs, HCO3- and H+ recombine to form CO2 and water. CO2 diffuses into alveoli and is breathed out.
56
Q

Explain why an increase in the partial pressure of CO2 leads to the increase in the dissociation of oxygen from oxyhaemoglobin.

A

carbon dioxide and water reacts to form carbonic acid (catalysed by carbon anhydrase)

carbonic acid dissociates to form hydrogen ions and hydrogen carbonate ions.

Hydrogen ions increase acidity of environment.

causes tertiary structure of haemoglobin to change

oxygen dissociates more readily from oxyhaemoglobin.

57
Q

Why does HCO3- not remain in the red blood cell?

A

So that there is space for more CO2 to undergo the reactions within the cell to convert to HCO3- ions.