8. Thyroid Pathology Flashcards
MEN 2a
Medullary carcinoma, pheochromocytoma, parathyroid adenoma
Sipple syndrome
Linked to RET proto-oncogene
MEN 2b (III)
Medullary carcinoma, pheochromocytoma, ganglioneuroma
Marfanoid habitus (tall, long arms and legs)
What is the effect of TH on bones?
Stimulates osteoclasts, bone resorption –> osteoporosis
Hyperthyroidism can cause arrhythmias esp ATRIAL FIB
FACT
FACT
Is HYPOthyroidism more common in men or women
Women
Most common cause of hypothyroidism in iodine sufficient parts of world
Hashimoto thyroiditis
What are the three antibodies found in hashimoto thyroiditis
Antimicrosomal
Antiperoxidase
Antithyroglobulin
What’s cretinism
Hypothyroidism in infants and neonates
Caused by maternal hypothyroidism or iodine deficiency
IMPAIRED FETAL BRAIN DEVELOPMENT –> mental retardation. Also see short stature, umbilical hernia, protruding tongue, coarse facial features
Myxedema (hypothyroidism) effect on cholesterol and vasculature
Inc cholesterol and LDL –> atherogenic
Genetic association with hashimoto
Ctla-4, hla-dr5
3 immuno mxn for damage in
Hashimoto
- Cytotoxic Cd8 T cell
- Cytokines (ifn gamma activate macrophages to cause damage)
- Autoantibodies
In which thyroiditis do you see a transient hyperthyroidism
Hashimoto
What thyroiditis is associated with B cell lymphoma?
Hashimoto thyroiditis
B cell non Hodgkin lymphoma esp marginal zone lymphomas of MALT
Subacute dequervians thyroiditis
granulomatous inflammation Neutrophil if infiltration Unknown cause Self limiting Tender thyroid
Goiter (include histo)
Def of iodine
Can in rare cases make thyroid hormone (hyper functioning)
TSH increases leads to hyperplasia of follicular cells
Flattened follicular cells, enlarged follicles, abundant colloid
