18. Male Hypogonadism Flashcards
What are the two lab studies that you should use to lok for testosterone administration safety
PSA and hematocrit
What is the effect of testosterone on RBC mass
Testosterone increases RBC mass
Klinefelter’s Syndrome
Leydig cell failure causes LH, FSH levels to inc. Low testosterone levels
Hypergonadotropin hypogonadism
Presenation: gynecomastia, inability to shave, reduced secondary male characteristics
Kallmann’s Syndrome
hypo-pituitary condition Impaired smell (anomsia) Hypogonadal hypogonadism (LH, FSH, testosterone are all low)
What is the protein that binds testosterone in the blood?
Sex Hormone Binding Globulin (SHBG)
What causes decreases in SHBG
Obesity
What determines if testerone level is low or if the testosterone level is low due to decreases amounts of SHBG
Free testosterone level test
Which drugs can decrease gonadotroins (LH, FSH) ( drugs total)
Narcotics Opiates (heroin) Alcohol Tranquilizers Sedatives Antihypertensives
When should testosterone be drawn?
in the morning when the levels are the highest
What is the normal testosterone range?
300-1100
What happens if you have XY but don’t have testosterone secretion in utero?
Hermaphrodites or testosterone resistant
Is gynecomastia from high or low testosterone?
Both high and low testosterone levels can cause gynecomastia
What percent of testosterone should be free?
2% is free testosterone
Differentiate between primary gonadal failure and secondary gonadal failure
Primary: high level of LH and FSH, low testosterone
Secondary: Low levels of LH and FSH, high testosterone
What is the most common cause of impotence?
DM
