8 Pharm of Adrenergics and Cholinergics on CNS

Question 1

Which neurotransmitters are excitatory?

Answer 1

glutamate and aspartate

Question 2

Which neurotransmitters are inhibitory?

Answer 2

GABA and glycine

Question 3

What receptor is responsible for enhancing memories for stimuli encoded under strong negative emotion (ie predicting danger)?

Answer 3

stimulation of beta-adrenergic receptors. Important in PTSD.

Question 4

What type of G couple receptor is alpha1

Answer 4

Gq

Question 5

What type of G coupled receptor is alpha2

Answer 5

Gi

Question 6

What type of G coupled receptor are beta recpetors?

Answer 6

Gs

Question 7

Which muscarinic receptors are coupled to Gq?

Answer 7

odds. M1,3,5

Question 8

Which muscarinic receptors are coupled to Gi

Answer 8

Evens. M2,4

Question 9

What would you give to treat PTSD intrusion (traumatic memories at night or during day)?

Answer 9

beta-adrenergic blockade

Question 10

What would you give to treat hyperarousal from PTSD?

Answer 10

alpha-adrenergic blockade

Question 11

MOA of paroxetine

Answer 11

SSRI.

Question 12

MOA of sertraline

Answer 12

SSRI

Question 13

ADE of beta blockers?

Answer 13

dizziness, confusion, fatigue, ahllucinations, emotial lability, insomnia

Question 14

ADE of antihistamines?

Answer 14

sedation and confusion.