8- Pathology of glomerulus and tubules and nephrotic syndrome

Question 1

What is amyloidosis

Answer 1

Extracellular deposition of amyloid- lodges in the glomerulus thus it cannot fucntion

Question 2

Name a dog breed that is predisposed to amyloidosis of the glomerlus

Answer 2

Shar-pei

Question 3

What is nephrotic syndrome?

Answer 3

Kidney disorder which causes a high amounts of protein to be passed in the urine

Damaged glomerular filtration barrier > leaks proteins into the filtrate
Reabsorption of the PC tubules ability is decreased (high protein filtrate in tubules) > High protein in the urine

Question 4

Name 2 clinical signs of nephrotic syndrome

Answer 4

Proteinuria, hypoproteinaemia, Hyperlipidaemia, generalised oedema

Question 5

What is glomerulosclerosis?

Answer 5

scarring of the glomerulus
Proteinuria > loss of antithrombin III > Thrombosis

Question 6

What condition is associated with white-spotted kidney in calves?

Answer 6

Non-suppurative interstitial nephritis

Question 7

what is glomerulonephritis

Answer 7

inflammation of glomeruli with secondary tubulointerstitial and vascular changes - damaged glomerular filtration barrier