8. hazards of transfusion Flashcards
cause of acute haemyltic transfusion reaction
ABO incompatibility
when does an acute haemolytic transfusion reaction usually ccur
1st 15mins of transfusion
type of haemolysis in acute haemolytic transfusion reaction
Intravascular
in an acute haemolytic transfusion reaction - what does the attachment of Ag and Ab cause?
complement - RBC membrane breakdown
what is the cause of delayed transfusion reactions?
non-detectable blood group Ab
when does delayed transfusion reaction occur?
5-10 days
what type of haemolysis in delayed transfusion reactions?
extravascular haemolysis
where does RBC breakdown occur in intravascular and extravascular haemolysis?
intra - within blood vessels
extra - liver/spleen
how is free haem removed in IV haemolysis?
binds to haptoglobin - complex is removed by reticuloendothelial system
how is free haem removed in EV haemolysis?
haem converted into bilirubin - degraded in liver
adverse effects of WBC transfusion
febrile reactions
variant Creutzfeldt-Jakob disease
TRALI
TAGvHD
when would you giev a human albumin solution transfusion?
- burn
- shock
- pt with low serum albumin
name a blood transfusion regulation bodu
hospital tranfusion committee
