8 - Flaviviruses and filoviruses

Question 1

What Baltimore class are flaviviruses?

Answer 1

Class IV

Question 2

What Baltimore class are filoviruses?

Answer 2

Class V

Question 3

What is the pathogenesis of HCV?

Answer 3

HCV proteins interfere with IFN pathways - prevents clearance of infected cells

HCV utilises host-derived lipids - dysregulation of lipid metabolism + fatty liver disease

Production of ROS - activation of hepatic stellate cells -> collagen secretion -> fibrosis -> DNA damage –> HCC

Question 4

What happens during the early stages of Ebola virus infection?

Answer 4

• Antigen presentation blocked in dendritic cells
• Macrophage infection -> release of NO and inflammatory cytokines -> damage to endothelial cells -> leakage of blood cells vessels -> haemorrhaging

Question 5

What happens during the late stages of Ebola virus infection?

Answer 5

Hepatocyte necrosis -> decreased production of coagulation factors

Adrenal cortical cells -> reduced production of steroid hormones that control BP

Endothelial cells -> disrupted cell adhesion + cell lysis

Sustained damage to blood vessels -> shock and multi-organ failure -> death