7.8 Overview of immunopathology Flashcards
What is endotoxic shock?
Triggered by excessive inflammation which is initiated by toll like receptors which recognise endotoxins
What is septic shock?
Caused by too high levels of pro-inflammatory cytokines and causes hypotension, exudation of IV fluids, multiple organ damage and failure, cytokine secretion, inflammation and clinical sepsis
What is the stereotypical presentation of auto inflammatory diseases?
Fever, serosiis, arthritis, uveitis, conjunctivitis, neutrophilic dermatosis and aphthosis
What are the syndromes of periodic fever?
Familial medeterranian fever Familial Hibernian fever Hyperglobulinemia D syndrome Muckel wells syndrome Familial cold urticarial CINCA Griscelli syndrome Cyclic neutropenia Familial TTP TNF-receptor associated period fever syndrome
Define inlammasomopathies
conditions with spontaneous fevers, arise from defects in regulation of production of IL-1
What causes Chron’s disease and what happens?
Mutations in NOD2 causing defective response to endotoxin or peptidoglycan. This causes aberrant response to GIT flora and spontaneous inflammation anywhere along the GIT with extra-intestinal features like arthritis and rash
What is type 1 hypersensitivity?
Immediate hypersensitivity and IgE-mediated leading to allergic response. Involves release of vasoactive mediators like histamine and serptonon.
What is type 2 hypersensitivity?
IgM or IgG mediated cytotoxic tissue damage (complement fixation or ADCC)
What is type 3 hypersensitivity?
Immune complex disease, circulating complexes of IgG and IgM deposit in capillary circulation
What is type 4 hypersensitivity?
Delayed type hypersensitivity and is cell mediated
What kind of hypersensitivity is post infectious nephritis?
Type 3
What are the three types of inappropriate antibody response
- Inappropriate isotype
- Abundance
- Specificity
