7.3.5 Acylation Flashcards
1
Q
How are acyl chlorides made?
A
- Substituting a Cl atom for the OH group
- In a carboxylic acid
- oyl Chloride
2
Q
How are acid anhydrides made?
A
- Substitution of OH group in a carboxylic acid
- With an alkanoate
- oic anhydride
3
Q
What reactions do acyl chlorides undergo?
A
- Nucleophilic addition-elimination reactions
- Eg. Hydrolysis, alcohols -> Esters, forming amides
4
Q
How does hydrolysis of Acyl chlorides work?
A
- Forms carboxylic acid and HCL
- Nucleophilic addition-elimination reaction
- H2O added across C=O bond
- HCl eliminated
5
Q
How does formation of esters work from acyl chlorides?
A
- React Acyl chlorides with Alcohols
- Forming esters
- Nucleophilic addition-elimination reaction
- OH adds across C=O bond
- HCL eliminated