7.3 Microfilaments II Flashcards
1
Q
What are the actin bundling proteins?
A
fimbrin (monomer), alpha actinin (dimer) and filamin (dimer)
2
Q
Alpha actinin
A
forms loose actin bundles (muscle fibers, focal adhesions)
3
Q
Villin and fimbrin
A
form tight actin bundles (microvilli)
4
Q
Filamin
A
forms actin meshwork by crosslinking existing filaments
5
Q
Spectrin
A
Membranes are linked to actin for support by spectrin as well as myosin I and other proteins
6
Q
Myosin I
A
links membranes to actin in microvilli
7
Q
Nucleation of actin is performed by ____ and inhibited by ____ and _____ creates the meshwork.
A
Profilin/Thymosin/Arp2/3
8
Q
Gelsolin is ____ activated.
A
calcium
9
Q
Ras family (Rac, Rho and CDC42) are _____ that coordinate actin assemblies
A
cell signaling proteins
10
Q
Platelet activation uses what 3 things?
A
Gelsolin, Fimbrin, Filamin
