7 schizophrenia Flashcards
1
Q
onset of schizophrenia? preceded by?
A
- late adolescence/early adulthood
- preceded by “prodromal” phase which reflects at-risk mental state
2
Q
neurological factors in schizophrenia
A
- underactivity in pfc during working memory and executive control tasks
- atypical connectivity between DL pfc and hippocampus during working memory challenge task
- decreased neurite density index in cortex, hippocampus, thalamus
3
Q
brain basis of auditory hallucinations
A
- Perisylvian region (between temporal and frontal lobe)
- decreased connections between lateral TP junction and Broca’s area
4
Q
genes for schizophrenia tend to be related to
A
- proteins expressed in the postsyn terminal
- esp those associated with glut pathway
5
Q
positive aspects of schizophrenia
A
high correlation with creativity
6
Q
meds for schizophrenia
A
- chlorpromazine (via dopamine receptor 2)
- other antipsychotics e.g. clozapine (bind to DR2 and serotonin receptor 2)
7
Q
anti-schizophrenic drugs are helpful for
A
reducing positive symptoms
