7. Older Persons Mental Health Flashcards
Which assessment tools can be used to assess cognitive ability?
- AMTS
- MMSE
- 4AT
What is implicit memory?
Unconscious memory systems, such as that responsible for conditioning and for motor tasks.
What is explicit memory?
Consciously learnt memory
What is working memory?
The amount of information that can be held by the brain ‘online’.
Causes lapses in short term memory if affected (e.g. forgetting why you opened the refrigerator door).
What is semantic memory?
The brain’s knowledge of objects and word meanings.
What is episodic memory?
Event-based memories, our own recollection of personally experienced episodes.
What is the prevalance of dementia in over 65s?
7%
What are some causes of dementia?
- Alzheimer’s disease (most common)
- Parkinson’s disease dementia
- Dementia with Lewy bodies
- Frontotemporal dementia
- HIV infection
- alcoholic dementia
- vascular dementia
What are the risk factors for Alzheimer’s disease?
- familial history
- increasing age
- hypertension
- depression
- low education
What are the pathological hallmarks of Alzheimer’s disease?
1) deposition of amyloid b-plaques in the cerebral cortex.
2) Tau proteins form neurofibrillary tangles, which replace the neuronal cytoskeleton.
3) Neuronal atrophy in the medial temporal lobes (ie. hippocampus).
Clinical features of Alzheimer’s disease.
- impairment of episodic memory
- severe forgetfulness
- problems managing day-to-day activities
- language impairments
- behavioural problems (e.g. anxiety, delusions)
- incontinence
As the disease progresses, symptoms become more disabling.
MRI findings in Alzheimer’s disease.
- symmetrical medial temporal lobe volume loss
What is the non-pharmacological treatment of Alzheimer’s disease?
Social support and increasing assistance with day-to-day activities:
- information and education
- carer support groups
- community dementia team
- community services (e.g. meals on wheels)
- day centre
- respite care
- residential home
What is the pharmacological management of Alzheimer’s disease?
- AChE inhibitors (e.g. donepezil, gelantamine, rivastigmine)
- NMDA antagonists (e.g. memantine)
What is the evidence behind
- AChE inhibitors
- NMDA antagonists
in the treatment of Alzheimer’s?
- Modest improvements of cognitive function, but no evidence they alter the overall cause of the disease.
- Combined with AChE provides benefit in some patients.
What is the pathology of frontotemporal dementia (FTD)?
Frontotemporal lobar degeneration:
- cortical and subcortical gliosis
- widened sulci
What are the risk factors for FTD?
- positive family history
Clinical features of behavioural FTD (bvFTD).
- socially inappropriate behaviour
- impulsive, careless decisions
- apathy
- loss of sympathy
- binge eating
- increased consumption of alcohol or cigarettes
- abnormal sexual behaviour with disinhibition
CT / MRI findings of bvFTD.
- frontal / anterior temporal atrophy
Clinical features of primary progressive aphasia.
Type of FTD:
- aphasia most prominent deficit