7. Immunopathology Flashcards
What is type I hypersensitivity and what is another name for it?
AKA Anaphylactic type; it?s hypersensitivity reaction that are characterized by IgE-related release of chemical mediators from mast cells and basophils. The release is triggered by exposure to an antigen but requieres prior sensitization to the antigen. Can be systemic (drugs or bee stings), or localized (food allergies, atopy or asthma).
What is type II hypersensitivity and what is another name for it?
AKA Cytotoxic type; it’s hypersensitivity reaction that are characterized by production of an IgG or IgM antibody directed against a specific targe cell or tissue.
What is type III hypersensitivity and what is another name for it?
AKA Immune complex disease; it’s hypersensitivity reaction characterized by the formation of in situ or circulating antibody antigen immune complexes, which deposit in tissue resulting in inflammation and tissue injury.
What is type IV hypersensitivity and what is another name for it?
AKA Cell-mediated type, it’s hypersensitivity reaction mediated by sensitized T lymphocytes.
What is complement-dependent cytotoxicity and give an example.
A type of type II hypersensitivity; it is the fixation of complements that result in osmotic lysis or opsonization of antibody coated cells/ e.i., autoimmune hemolytic anemia.
What is antibody-dependent cell mediated cytotoxicity (ADCC) and give an example.
A type of type II hypersensitivity; it is cytotoxic killing of an antibody-coated cell, e.i., pernicious anemia.
What is anti-receptor antibody reaction and give an example.
A type of type II hypersensitivity; it is when antibodies activate or interfere with receptors, e.i., Graves disease.
What are three examples of type III hypersensitivity?
I. Serum sickness. II. Systemic lupus erythematosus (SLE). III. Glomerulonephritis.
What is delayed type hypersensitivity?
A type of type IV hypersensitivity, it is when CD4+ T-cell lymphocyte mediate granuloma formation seen in tuberculosis and PPD skin test.
What is cytotoxic T-cell mediated reaction?
A type of type IV hypersensitivity, it is when CD8+ T-cell lymphocytes destroy antigen-containing cells seen in viral infections, immune reaction to tumors, contact dermatitis, and graft rejection.
What is systemic lupus erythematosis (SLE)?
Chronic systemic autoimmune disease characterized by loss of self-tolerance and production of autoantibodies.
What mechanism of injury does systemic lupus erythematosis inflict on the body?
Type II and III hypersensitivity.
What are the clinical signs of systemic lupus erythematosis?
Hematologic (hemolytic anemia, thrombocytopenia, neutropenia, lymphopenia), arthritis (polyarthralgia and synovitis without joint deformity), Skin (malar “butterfly” rash, maculopapuplar rash, ulcerations and bullae formation), Heart (Libman-Sacks endocarditis (nonbacteral verrucous endocarditis), Serosal surface (pericarditis, pleuritis, and pleural effusions), and CNS (focal neurologic symptoms, seizures, and psychosis).
According to WHO classification of kidney manifestation of lupus, what is Class I?
Normal.
According to WHO classification of kidney manifestation of lupus, what is Class II?
Mesangial lupus nephritis.
According to WHO classification of kidney manifestation of lupus, what is Class III?
Focal proliferative glomerulonephritis.
According to WHO classification of kidney manifestation of lupus, what is Class IV?
Diffuse proliferative glomerulonephritis (most common and severe).
According to WHO classification of kidney manifestation of lupus, what is Class V?
Membranous glomerulonephritis.