10. Environment and Lifestyle-Related Pathology Flashcards
What is pneumoconioses?
Fibrosing pulmonary disease caused by inhalation of an aerosol (mineral dusts, particles, vapors, or fumes).
What is anthracosis?
When carbon pigment (anthracotic pigment) accumulates in macrophages along the pleural lymphatics. It is asymptomatic.
What is simple coal worker’s pneumoconiosis?
AKA black lung disease, coal-dust macules and nodules in the upper lobes. Little pulmonary dysfunction.
What is complicated coal worker’s pneumoconiosis?
Progressive massive fibrosis with increasing respiratory distress. May progress to pulmonary hypertension and cor pulmonale.
What is Caplan syndrome?
Pneumoconiosis and rheumatoid arthritis.
Which type of asbestos is associated with being more pathogenic and highly associated with mesotheliomas?
The amphibole kind which are straight and brittle fibers. There are crocidolite, tremolite and amosite subtypes. Serpentine are not so much pathogenic and are curved, flexible fibers with chrysolite subtype.
What happens in asbestosis?
Diffuse interstitial fibrosis, which is most severe in the lower lobes. Asbestos bodies that may become coated with iron (ferruginous bodies). Slowly progressive dyspnea that may progress to pulmonary hypertension and cor pulmonale.
What other syndrome is associated with asbestosis?
Caplan syndrome.
How is silicosis acquired?
Exposure to silicon dioxide (silica).
What is the most common type of tumor in asbestos-exposed individuals?
Bronchogenic carcinoma.
What are the clinical symptoms of malignant mesotheliomas?
Recurrent pleural effusions, dyspnea and chest pain. There is an encasement and compression of the lungs. Micro: carcinomatous and sarcomatous elements (biphasic parttern).
What do we seen in X-ray of someone with silicosis?
Fibrotic nodules in the upper zones.
What are the clinical symptoms of silicosis?
Insidious onset of dysnea, slowly progressive despite cessation of exposure.
How does berylliosis damage the lungs?
Causes type IV hypersensitivity reaction, resulting in granuloma formation.
What does acute exposure to beryllium cause?
Acute pneumonitis.