6.5. STEM CELLS Flashcards
1
Q
What are stem cells?
A
- undifferentiated cells
2
Q
What happens once stem cells become specialised?
A
- lose ability to divide
- enter G0 phase of the cell cycle
3
Q
Why does the activity of stem cells have to be strictly controlled?
A
- if they do not divide fast enough, tissues are not efficiently replaced, leading to ageing
- if division is uncontrolled, form masses of cells (tumours), which can lead to cancer
4
Q
What does “stem cell potency” mean?
A
- a stem cells ability to differentiate into different cell types is called potency
- greater the number of cell types it can differentiate into, the greater its potency
5
Q
What are the three types of stem cell potency?
A
- totipotent
- pluripotent
- multipotent
6
Q
What does totipotent mean?
A
- these stem cells can differentiate into any type of cell
- e.g. zygotes/ fertilised egg to eventually produce a whole organism
- also differentiate into extra-embryonic tissues like the amnion and umbilicus
7
Q
What does pluripotent mean?
A
- these stem cells can form all tissue types but not whole organisms
- present in early embryos
- origin of different types of tissue within an organism
8
Q
What does multipotent mean?
A
- these stems cells can only form range of cells within a certain type of tissue
- e.g. haematopoietic stem cells in bone marrow, they give rise to various types of blood cell.
9
Q
What have multicellular organisms like plants and animals evolved from?
A
- unicellular organisms (single-celled)
10
Q
Where are blood cells derived from?
A
- stem cells in bone marrow
11
Q
How long are erythrocytes’ lifespans?
A
- 120 days (approx.)
- so need to be replaced constantly
12
Q
How many erythrocytes are produced by stem cell colonies in the bone marrow?
A
- approx. 3 billion per kilogram of body mass per day
13
Q
How long are neutrophils’ lifespans?
A
- 6 hours
14
Q
How many neutrophils are produced by stem cell colonies in the bone marrow?
A
- approx. 1.6 billion per kg of body mass per hour
- increases during infection
15
Q
What are the sources of animal stem cells?
A
- embryonic stem cells
- tissue (adult) stem cells