65 - Melanocyte Biology

Question 1

what is Vogt-Koyanagi-
Harada syndrome

Answer 1

autoimmune disease represend the embaryonic spread of melanoctyes on the leptomeninges, inner ear, and skin.
responsible for the aseptic meningitis, auditory symptoms, and areas of vitiligo-

Question 2

what is

Waardenburg syndrome

Answer 2

Aberrant migration or survival of melanocytes within the inner ear, the iris, and midportions of the forehead and extremities explains the presence of congenital deafness, heterochromia irides, and patches of leukoderma, respectively, in patients with Waardenburg syndrome

mutations in MITF lead to Waardenburg syndrome

aberrant migration or survival of enteric ganglion cells, another neural crest derived cell population, provides an explanation for the association of aganglionic megacolon