6.23.16 Block 1 Flashcards

1
Q

Aortic regurg: ssx

A
  • dyspnea
  • weak
  • hypotension
  • widened pulse pressure
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2
Q

CASE: 56yo F –> weak & dizzy for 5 days –> SOB, 154/52 BP –> what murmur?

A

AR

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3
Q

AR: goal of tx? why?

A

reduce afterload: decrease myocardial wall stress –> optimize LV fx

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4
Q

what drugs are afterload reducers?

A
  • hydralazine

- ACEI

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5
Q

Rhus dermatitis: what type of rxn?

A

delayed type IV HSN

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6
Q

poison ivy: what type of rxn?

A

delayed type IV HSN

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7
Q

poison ivy: leads to?

A

Rhus dermatitis

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8
Q

trt rib exhalation SD: mnemonic

A

I woke up at 1AM 2P bc bw 3-5PM I had 6-9 Sam Adams and Laid Down bw 10-12

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9
Q

CASE: respiration –> rib moves up but not down –> dx?

A

inhalation SD, exhalation restriction, locked up

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10
Q

where is the key rib in a inhalation SD?

A

inferior rib

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11
Q

pyelonephritis: first line tx

A

fluoroquinolone + TMP/SMX

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12
Q

pyelonephritis: 2nd line tx

A

amoxicillin-clavulanate for preg & children

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13
Q

what is: flutamide

A

antiandrogen

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14
Q

flutamide: MOA

A

inh androgen axn at testosterone receptor

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15
Q

flutamide: use

A

androgen deprivation in adv prostate CA

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16
Q

advanced prostate cancer: tx

A

flutamide

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17
Q

DHT: effect on prostate

A

develop & enlarge

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18
Q

benign prostatic hyperplasia: tx

A

finasteride

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19
Q

danazol: what is? MOA?

A

andogren –> suppress mid-cycle surge of FSH & LH –> reduce estrogen production from ovary

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20
Q

what is: clomiphene

A

infertility drug to induce ovulation

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21
Q

anastrazole: MOA

A

inh aromatase –> androgen cannot convert to estrogen

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22
Q

anastrazole: use

A

adv hormone receptor+ breast CA –> esp those resistant to tamoxifen

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23
Q

Schilling test: use

A

confirm that IF def is causing cobalamin def

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24
Q

B12 def: ssx

A
  • UMN signs

- proprioceptive changes

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25
Q

osteophytes: seen in OA or RA?

A

OA

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26
Q

RA: useful lab tests? results?

A
  • RF
  • CRP
  • ESR

all elevated

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27
Q

OA: affects what bones?

A

wtbearing joints –> knee, hip, cervical, lumbosacral, feet

28
Q

OA: classic presentation

A
  • wtbearing joints –> pain after use, improve w rest

- morning stiff 50yo

29
Q

OA: is it inflamm or non-inflamm?

A

non-inflamm ==> normal acute phase reactants

30
Q

UE: sensory dermatomes

A
C5: lat elbow
C6: thumb
C7: middle 
C8: pinky
T1: med elbow
31
Q

LE: sensory dermatomes

A
L2: medial thigh
L3: med knee
L4: med malleolus
L5: dorsum of foot
S1: lat malleolus
32
Q

UE reflexes: nerve roots

A

biceps: C5
brachioradialis: C6
triceps: C7

33
Q

Wiskott-Aldrich synd: triad

A
  • thrombocytopenia
  • eczema
  • recurrent infect
34
Q

Wiskott-Aldrich synd: describe

A

XR –> decrease T & B cells –> decrease IgM

35
Q

CASE: 10mo white M –> otitis media, sinusitis, pneumonia –> dry skin, petechiae, prolonged bleeding –> dx?

A

Wiskott-Aldrich

36
Q

Finkelstein’s test: what is a positive test?

A

thumb in fist –> ulnar deviate –> pain in distal radisu

37
Q

+Finkelstein’s test: indicates?

A

De Quervains’ tenosynovitis - inflamm of tendons of thumb

38
Q

what are the tendons of the 1st finger?

A

SEX LAP:

  • long abductor pollicis
  • short extensor pollicis
39
Q

what increases the effectiveness of local anes?

A
  • low intracell pH

- high extracell pH

40
Q

carcinoid synd: tx

A

octreotide

41
Q

what is: octreotide

A

somatostatin analog

42
Q

carcinoid synd –> at risk for what vit def? why?

A

niacin

  • carcinoid –> use tryptophan –> produce excess serotonin
  • all tryptophan used up –> can’t make niacin
43
Q

tryptophan: precursor to?

A
  • serotonin

- niacin

44
Q

carcinoid synd: leads to what heart disorder? why?

A

R valve defect: serotonin stenose tricuspid valve

45
Q

what are C fibers?

A

paleospinothalamic tract: slow, poorly localized pain

46
Q

what are A fibers?

A

neospinothalamic tract: fast, well localized pain

47
Q

what are the 2 fxal cmpts to pain sensation?

A

1) paleospinothalamic: ache, diffuse/poorly localized pain

2) neospinothalamic: well localized

48
Q

what is the most common ankle sprain?

A

ant talofibular lig

49
Q

ant talofibular lig: insertions

A

lat malleolus –> neck of talus

50
Q

what is: cataplexy

A

strong emotional stimulus –> brief episode of bilat weak without LOC

51
Q

cataplexy seen in what disorder?

A

narcolepsy

52
Q

CASE: drink lots of alcohol –> acute abd pain, discolored urine –> dx?

A

acute intermittent porphyria

53
Q

what increases heme syn?

A
  • alcohol
  • barbiturate
  • OCP
54
Q

what is the most restful & replenishing stage of sleep?

A

stage 3

55
Q

why do infants require large amounts of sleep?

A

stage 3 –> largest amt of growth hormone released at this time

56
Q

LDL receptor binding to chylomicrons involves what Apo?

A

B48, E

57
Q

CASE: M infant –> vomit, abd pain, bloody stool –> dx?

A

intussusception

58
Q

what is most common cause of intestinal obstruction in infants?

A

intussusception

59
Q

intussusception: classic triad

A
  • vomit
  • abd pain
  • currant jelly stool
60
Q

what is most common cause of intestinal obstruction by pop?

A

> 2mo: midgut volvulus
6-36mo: intussusception
M –> middle age-elderly: sigmoid volvulus

61
Q

growth hormone def: effects

A
  • altered lipid metab –> increase subQ visceral fat
  • decrease muscle mass
  • decrease bone density
  • low exercise performance
  • reduced QOL
62
Q

growth hormone def: signs

A
  • decrease gluconeogenesis –> hypoglycemia
  • loss of muscle mass
  • osteopenia, osteoporosis
63
Q

what N provides sensation to ant tongue?

A

lingual N

64
Q

CN V3: sensory to?

A
  • ant tongue
  • mandibular teeth
  • lower face
65
Q

what N provides taste to ant tongue?

A

chorda tympani

66
Q

what is the confirmatory lab test for preg?

A

B-hCG

67
Q

what produces B-hCG?

A
  • initially: developing embryo

- after implantation: syncytiotrophoblast