6. Treatment of peptic ulcers

Question 1

What do parietal cells secrete

Answer 1

HCl
Pepsin
Intrinsic factor
Mucus

Question 2

Stimulation of gastric acid secretion

Answer 2

Only in parietal cells
Enterocromaffin-like cells lie deep in the oxyntic glands
ECL secrete histamine in response to gastrin
Gastrin is formed in the antrum of the stomach
ECL can also be stimulated by hormones

Question 3

Acid stimulation by gastrin

Answer 3

Gastrin secreted by gastrin cells
Located in pyloric glands
ECL release histamine into the oxyntic cells
ECL stimulates HCl release

Question 4

Inhibition of gastric secretion

Answer 4

Reverse reflex initiated by:
Distension of small bowel
Acid in the upper intestine
Presence of protein breakdown products
Irritation of mucosa
Secretin

Question 5

H.pylori infection directly associated with

Answer 5

Peptic ulcer disease
Gastric carcinoma
MALT lymphoma

Question 6

Consequences of helicobacter infection

Answer 6

Peptic ulcer disease
Distal gastric adenocarcinoma
Primary gasstric MALT
Dyspepsia

Question 7

Cimetidine

Answer 7

H2 blocker
Cytochrome P450 inhinitor
Affects hormone metabolism
Interferes with tricyclines and serotonin reuptake inhibitors

Question 8

Rantidine

Answer 8

Similar to cimetidine

Can cause malaise and dizziness

Question 9

Histamine blockading drugs

Answer 9

Reduce gastric acid by reducing stimulation of the oxyntic cells via the histamine pathway