6. Mycoplasma & Chlamydia Flashcards
Does chlamydiae obligate intracellualr pathogens?
Yes
How do chlamydiae differ from other bacteria?
- have no peptidoglycan in their cell wall
- do not produce ATP —> need host ATP —> energy parasites
- growth cycle ( biphase life cycle)
Chlamydiae EB?
- elementary bodies
- extracellular form
- infective form
Chlamydaie RB?
- reticulate bodies
- intercellular form
- replicative form
Common chlamydiae pathogens?
- chlamydia trachomatis
- chlamydia psittaci
- chlymydia pneumoniae
What are the Ocular infections of chlamydia trachomatis?
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- Trachoma (common in children, spreads by flies or fingers, imp cause of blindness)
- Adult inclusion conjunctivitis ( speards from genetalia to eye, common in sextually active young ppl, self limiting)
- Chlamydial opthalmia neonatorum ( neonates 1-3 weeks after birt, source is the mother’s birth canal)
What are the genital infections of Chlamydiae trachomatis ? (Males)
- non-gonococcal urethritis
- genital ulcer & lymphadenopathy known as lymphgranuloma venereum / LGV —> Found in tropics
What are the genital infections of chlamydaie trachomatis? (Females)
- urethritis & cervicitis
- endometritis & salpingitis —>
- ectopic pregnancy & infertility
What are the respiratory infections of chlamydaie trachomatis?
-neonatal pneomonitis
Chlamydia pneumonaie clinical infections?
- otitis media & sinusitis
- pneumonia & bronchitis
Chlamydia psittaci clinical infections?
- Psittacosis or ornithosis
- non- human pathogen / zoonotic infection
- droplet infection
- bird handlers
- atypical pneomonia
What are mycoplasma?
*Bacteria that lack cell wall and can grow in rich artificial media
* 3 species are s=associated w/ infection in humans
1- mycoplasma hominis
2- ureaplasma urealyticum
3- mycoplasma pneumoniae
What are the respiratory infections of mycoplasma pneumoniae?
Atypical pneumonia
- children are more affected
- more during summer
- prominant X-ray findings
- disease course >2 weeks
- HEMOLYTIC ANEMIA
Mycoplasma pneumoniae extrapulmonary manifestion?
- hemolytic anemia
- myocarditis
Diagnosis of mycoplasma pneumonia?
- serology
- IgG & IgM
- Rapid diagnosis
- Molecular
- Cold agglutinin test
Treatment of mycoplasma pneumonia?
- erythromycin
- shouldnt use any antibiotic act on cell wall, why?
What are the genital infections of mycoplasma hominis & ureaplasma urealyticum? (Males - females)
Males: -non-gonococcal urethritis Females: - pelvic inflammatory disease PID - abortion & pretern labor - stillbirth
