6. Coagulation Tutorial Flashcards
Stages of clotting (3)
(Bleeding)
Vasoconstiction
Platelet plug formation
Coagulation
Common inherited coagulopathies (3)
Haemophilia
Thombophilia (protein C deficiency, protein S deficiency, FV leiden, antithrombin III deficiency)
von Willebrand disease
Definition and function of antithrombin III
Glycoprotein (produced in the liver)
Inactivates several coagulation system pathways
Definition and function of Protein C
Vitamin-K dependent glycoprotein
Regulates anticoagulation, inflammation, cell death and maintains BV wall permeability
Deficiency can cause significantly increased thrombosis risk
Definition and function of Protein S
Vitamin-K dependent glycoprotein
Co-factor to protein C in the inactivation of FVa and FVIIIa
Description of platelet plug formation (2)
Platelets tick together to form a temporary seal to cover break in vessel wall
Activated by vWF in plasma
Description of coagulation
Reinforces platelet plug with insoluble fibrin (molecular glue)
What is DDAVP
Desmopressin
Uses of DDAVP (4)
Treat diabetes insidious
Treat haemophilia A
Treat von Willebrand disease
Treat high blood urea levels
DDAVP side effects (4)
Headaches
Diarrhoea
Low blood sodium
Release FVIII
Function of antifibrinolytic agents
Inhibit fibrinolysis by interfering with plasmin formation
Common reasons for thrombophilia (4)
Antithrombin III deficiency
Protein C deficiency
Protein S deficiency
Factor V leiden variant
Examples of FXa inhibitors (2)
Rivaroxiban
Apixiban
Example of direct thrombin inhibitor
Dabigatran
Blood tests used for bleeding (3)
Platelets
FBC
Bleeding time
