6-Cholinomimetics

Question 1

What does the M1-type receptor do and where is it present?

Answer 1

Linked to Gq - increased phospholipase C, increased PIP2->IP3 and DAG, increased Ca2+ and contraction
Salivary glands, Stomach, CNS

Question 2

What does the M2 receptor do and where is it present?

Answer 2

Linked to Gi, reduces adenylate cyclase, less cAMP, less PKA, less Ca2+ and relaxation
Heart

Question 3

What does the M3 receptor do and where is it present?

Answer 3

Linked to Gs, increases adenylate cyclase, less cAMP, more PKA, more Ca2+ and constriction
Visceral smooth muscle, bronchioles, eyes (pupillary sphincter and ciliary muscle) and exocrine glands