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Pharmacology > 3-Pharmacokinetics and Metabolism > Flashcards

3-Pharmacokinetics and Metabolism Flashcards

1
Q

What does the pKa of a molecule tell you?

A

The pH at which it is HALF dissociated
For an acid, if pH>pKa, it will be ionised,polar,water-soluble and not absorbed well in the stomach
For an acid, if pH

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2
Q

What factors affect distribution?

A

Regional blood flow
Extracellular/plasma-protein binding
Capillary permeability
Localisation in tissues

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3
Q

How do most acidic drugs exist in the blood?

A

Heavily plasma protein bound - 50-80%

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Pharmacology (8 decks)

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