5-Drug Metabolism

Question 1

List the Phase I reactions

Answer 1

Oxidation, Reduction, Hydrolysis

Question 2

What is the purpose of Phase 1 reactions?

Answer 2

To add/unmask a functional group to serve as a point of attachment for Phase 2 reactions
Little change in polarity

Question 3

List the Phase 2 reactions

Answer 3

Glucuronidation, Acetylation, Amino acid conjugation, Methylation, Sulphation, Glutathione conjugation