6. Alpha Thalassemia

Question 1

Silent carrier genotype

Answer 1

-a / aa (hetero a+)

Question 2

Hgb H disease genotype

Answer 2

• • / -a (hetero a+/a0)

Loss of 3 a-gloublin genes

Question 3

Hetero a+ genotype

Answer 3

-a / aa

Question 4

Homo a0 genotype

Answer 4

• • / - -

Question 5

Hetero a0 genotype

Answer 5

• • / -a

Question 6

Alpha thal 2 minor genotype

Answer 6

• a / - a

Question 7

Why is alpha thalassemia phenotype associated w/ allelic heterogeneity?

Answer 7

Many DNA mutations of diff types can all lead to alpha thal

Question 8

Homo a+ genotype

Answer 8

-a / -a

Question 9

Alpha thal 1 minor genotype

Answer 9

• • / aa