6/6 Mixed Flashcards
Standard deviation
mean +/- 1.96*SD would cover 95% of the observations
Mean +/- 2.58*SD would cover 99% of the observations
Hyperimmunoglobulin M (hyper-IgM)
Defective immunoglobulin class switching due to a defect in CD40 ligand-CD40 interaction
Absence of CD40 ligand is the most common cause and is inherited in an X-linked recessive pattern
Recurrent sinopulmonary, GI, and opportunistic infections
Mycoplasma antibiotic resistance
All organisms in the mycoplasma genus lack peptidoglycan cell walls and therefore resistant to agents that attack the peptidoglycan cell wall such as penicillins, cephalosporins, carbapenems, and vancomycin
Rx with anti-ribosomal agents (tetracycline, macrolides)
Age 3 development
Play imaginatively in parallel, speak in simple sentences (3 words), copy a CIRCLE, use utensils, and ride a tricycle
CFTR protein
chromosome 7
transmembrane ATP-gated chloride channel
Location of left kidney
Lies immediately deep to the tip of the 12th rib
Luekomoid reaction
Benign leukocytosis (>50,000) that occurs in response to an underlying condition such as severe infection/hemorrhage, malignancy (Leukemia) or acute hemolysis
Leukocyte alkaline phosphatase levels are normal or increased
Peripheral smear can show increased bands, early mature neutrophil precursors (myelocytes) and granules (Dohle bodies) in the neutrophils “basophilic oval inclusions in mature neutrophils”
Glioblastoma
Most common primary cerebral neoplasm of adults that is typically located within the cerebral hemispheres and may cross the midline
These tumors are highly malignant and grossly contains areas of necrosis and hemorrhage
First and zero order kinetics
In first order kinetics, a constant FRACTION (or proportion) of drug is metabolized per unit of time, so the amount metabolized changes based on the serum concentration
In zero-order kinetics, a constant amount of drug is metabolized per unit time, independent of serum levels
Hypertrophic cardiomyopathy
Dynamic left ventricular outflow tract obstruction is due to abnormal systolic anterior motion of the anterior leaflet of the mitral valve toward a hypertrophied interventricular septum
Gaucher disease
AR, lysosomal storage disorder that is characterized by B-glucocerebrosidase deficiency and presents with pancytopenia and hepatosplenomegaly
Glucocerebroside accumulation leads to distended macrophages with a “wrinkled tissue paper” appearance, also known as Gaucher cells
Renal artery stenosis
Causes renal hypoperfusion and activation of the RAAS
Modified smooth muscle (juxtaglomerular) cells of the afferent glomerular arterioles synthesize renin
This leads to a cascade of effects that include systemic vasoconstriction (ATII) and sodium and water retention (aldosterone and ATII)
Chronic renal hypoperfusion will cause hypertrophy and hyperplasia of the juxtaglomerular cells
Communicating hydrocephalus
Symmetrical enlargement of the ventriculi
Usually occurs secondary to dysfunction or obliteration of subarachnoid villi
This is usually a sequelae of meningeal infection (including tuberculosis meningitis) or subarachnoid/intraventricular hemorrhage)
Acute hepatitis A
Self-limited infection that typically presents acutely with prodromal symptoms (fever, malaise, anorexia, N/V, right upper quadrant pain) followed by signs of cholestasis (jaundice, dark-colored urine, clay-colored stool)
Livery biopsy: spotty hepatocyte necrosis and inflammatory cell infiltration
Alpha 1 receptor stimulation of eye
Causes contraction of the ocular pupillary dilator muscle, resulting in mydriasis (pupillary dilation)