5a] Immunologic

Question 1

Protection against infectious organisms

Answer 1

Immune system

Question 2

Two types of immunity

Answer 2

Humoral and cell-mediated

Question 3

4 ways to classify immuno dysfunctions

Answer 3

1- immunodeficiency
2- hypersensitivity
3- autoimmune
4- immunoproliferative

Question 4

Inflammation of disarthrodial joints

Answer 4

RA

Question 5

3 stages that RA progresses in

Answer 5

1- synovium swelling
2- rheumatoid nodules develop
3- erosion of bone, cartilage-enzyme release

Question 6

Hallmark sign of RA in radiograph

Answer 6

Articular erosion

Question 7

Who is RA most common in ?

Answer 7

Women 20-40

Question 8

Risk factors for RA

Answer 8

Genetic susceptibility (HLA-DR4)
Hormones in women
Trigger: infection, environment, stress

Question 9

Signs and Sx of RA

Answer 9

Constitutional Sx
Joint pain, swell, warm, red, stiff
Morning stiffness
+ RA factor

Question 10

What joints are affected in RA

Answer 10

MTP
MCP
PIP
Wrist and knees

Question 11

Joint pain in RA is usually,,,

Answer 11

Bilateral

Question 12

Dx of RA- ACR criteria - how many must be present?

Answer 12

4 out of 7

Question 13

ACR criteria for Dx of RA

Answer 13

1- morning stiff more than an hour
2- soft tissue swell in hands
3- soft tissue swell in 3 out of 14 joint groups
4- symmetrical swelling in 1 joint area
5- rheumatoid nodule
6- + RA factor
7- radiograph changes in hands or wrist

Question 14

Subchondral cyst formation

Answer 14

RA and OA

Question 15

Joint space narrowing

Answer 15

RA and OA

Question 16

Bony erosion at joint margins - hallmark sign

Answer 16

RA

Question 17

Osteophytosis- hallmark sign

Answer 17

OA

Question 18

Periarticular osteopenia

Answer 18

RA

Question 19

Subchondral sclerosis

Answer 19

RA

Question 20

Joint sublux

Answer 20

RA

Question 21

Ankylosis

Answer 21

RA

Question 22

Example of immunodeficiency

Answer 22

AIDS

Question 23

Examples of hypersensitivity

Answer 23

Allergies to drugs
Contact dermatitis
Transplant rejection

Question 24

5 examples of autoimmune

Answer 24

Fibromyalgia
RA
SLE
Polymyalgia rheumatica 
Spondyloarthropathies (Guilin-Barre)

Question 25

Example of immunoproliferative

Answer 25

Leukemia

Question 26

Tenderness in fibromyalgia

Answer 26

Pain with light touch

Question 27

Widespread- lasting more than 3 months

Answer 27

Fibromyalgia

Question 28

Localized pain

Answer 28

Myofascial pain

Question 29

Tender points = “pain” is + response

Answer 29

Fibromyalgia

Question 30

Trigger points- hallmark

Answer 30

Myofascial pain

Question 31

No associated signs and Sx

Answer 31

Myofascial pain

Question 32

Aches and pains
Stiff
Swelling in soft tissue
Muscle spasms/nodules

Answer 32

Fibromyalgia

Question 33

4 types of hypersensitivity disorders

Answer 33

1- anaphylactic (allergies)
2- cytolytic or cytotoxic
3- immune complex
4- Cell meditated or delayed

Question 34

Caused by production of auto antibodies against self cells or tissues that have foreign protein attached

Answer 34

Type 2 hypersensitivity (cytolytic or cytotoxic)

Question 35

Results from formation of antigen-antibody complexes in tissue

Answer 35

Type 3 hypersensitivity (immune complex)

Question 36

Allergy, autopsy, anaphylaxis

Answer 36

Type 1 hypersensitivity (anaphylactic)