5.4 Malaria prophylaxis

Question 1

Pregnancy 1st line treatment

Answer 1

Chloroquine

Question 2

Treatment in 2nd/3rd trimester pregnancy

Answer 2

Mefloquine

Question 3

What antimalaria prophylaxis treatments is avoided in pregnancy?

Answer 3

Doxycycline - last resort and entire course needs to be finished before 15 week gestation

Atovaquone with proguanil - last resort use in 2nd/3rd trimester + folic acid

Question 4

Epilepsy first line treatment

Answer 4

Doxycycline or Atovaquone with proguanil

Question 5

What antimalaria prophylaxis treatments is avoided in epilepsy?

Answer 5

Chloroquine + Mefloquine

Question 6

Doxycycline counselling points?

Answer 6

• Protect skin from sunlight
• Do not ingest remedies = Iron/Zinc - 2hrs before or after
• capsules swallowed whole during meals while sitting or standing

Question 7

MHRA alert for chloroquine?

Answer 7

Ocular toxicity if dose exceeds 4mg/kg daily

Question 8

Chloroquine and what medication can increase risk of CVD and Psychiatric reactions?

Answer 8

Macrolide treatment