(5.2) Comprehensive Clinical Review (Fever) [Tyler] Flashcards
Fever is a rise in body temperature in response to ______
Endogenous cytokines
Fever is controlled by the _____ area of the hypothalamus
Preoptic
What cytokines act on the thermoregulatory portion of the hypothalamus?
Endogenous Pyrogens (IL-1, TNF, interferon alpha)
What is the most common cause of fever in hospitals?
Community-acquired infection (51%)
What is the most common cause of fever of unknown origin (FUO)?
Infection (tuberculosis, intra-abdominal abscess)
Why do night sweats occur?
Exaggeration of normal circadian temperature rhythm
What are the diagnostic criteria for fever of unknown origin (FUO)?
Fever >101 F
Illness >3 weeks
No known immunocompromised state
Dx remains uncertain even after thorough hx of lab workup
When would you give antibiotics for fever of unknown origin?
If sepsis or toxicity is apparent
What demographics represent the highest risk group for fever of unknown origin?
>65 yo
Chronic disease
Usually have bacterial infection
Alarm sx for fever?
Fever >105 F
Rash
Change in mental status/level of sensorium
Dizziness/lightheadedness
Recent chemotherapy
SOA/chest pain
Alarm sx for fever:
Considerations for fever >105 F?
CNS infection
Neuroleptic Malignant Syndrome (NMS)
Heat stroke
Alarm sx for fever:
Considerations for rash?
Meningitis
Bacteremia w/ septic shock
Rickettsial disease
Bacterial endocarditis
Benign causes - viral exanthem, drug fever
Alarm sx for fever:
Considerations for change in mental status/level of sensorium?
Meningitis
Neuroleptic malignant syndrome (NMS)
Heat shock
Encephalitis
Bacterial infections with septic shock
Alarm sx for fever:
Considerations for dizziness, lightheadedness?
Bacterial infection with septic shock
Adrenal insufficiency
PE
benign - viral infection with labyrinthitis
Alarm sx for fever:
Considerations for recent chemotherapy?
Nosocomial infection with neutropenia
Alarm sx for fever:
Considerations for SOA and chest pain?
PE
Pneumonia
Empyema
Malarial infection may have what fever patterns?
Teritan (48 hours)
Quartan (72 hours)