5. Overview of CNS/PNS and Embryo Flashcards

1
Q

Major Segments of the Brain and what they include (5)

A
  1. Telencephalon-cerebral hemispheres
  2. Diencephalon-hypothalamus and thalamus
  3. Mesencephalon-midbrain
  4. Metencephalon-pons and cerebellum
  5. Rhombencephalon-medulla
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2
Q

Gray v White Matter

A

Gray=neurons, white=axons; in brain gray is outer and white is deep; in spinal cord white is outer and gray is deep

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3
Q

5 major subdivisions of the forebrain

A
frontal
parietal
temporal
limbic
occipital
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4
Q

Basal Ganglia (4) and general function

A
Basal Ganglia smooths out motor movements
Caudate Nucleus
Putamen
Globus Pallidus Externa
Globus Pallidus Interna
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5
Q

Numbers of Cord Segments and Vertebrae

A

8 Cervical Segments, 7 Cervical Vertebrae
12 Thoracic Segments and 12 Vertebrae
5 Lumbar Nerves and 5 Vertebrae
5 Sacral Nerves with fused sacral bone

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6
Q

Where does spinal cord end?

A

T12-L1

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7
Q

Who sits in the back of the spinal cord bus? Front?

A

Afferent Sensory are the cool kids

Efferent Motor are the med students

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8
Q

What is the only motor pathway to the periphery that we must learn?

A

Corticospinal (pyramidal) Tract

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9
Q

Describe Pyramidal Tract generally

A

Motor Cortex–>post internal capsule–>decussate at decussation of pyramids–>lateral corticospinal tract–>terminate on LMN in anterior horn–>ventral spinal root–>peripheral nerve–>muscle

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10
Q

Spinothalamic Tract senses what?

A

pain and temperature from periphery

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11
Q

Describe Spinothalamic Tract generally

A

pain/heat–>peripheral nerve–>thru DRG into dorsal spinal cord–>up/down 1-2 segments in Lissauer’s Tract–>Synapse in post horn–>2ndary neuron decussates and travels in anterolateral spinothalamic tract–>terminates in VPL of thalamus–>3rd neuron thru internal capsule to somatosensory cortex

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12
Q

Posterior (Dorsal) Column senses what?

A

vibration and position changes

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13
Q

Describe Posterior Column Tract generally

A

vibes/movement–>thru DRG into dorsal spinal cord –>ascends ipsilateral in posterior column–> synapse in gracile/cuneate nuclei–>decussate as internal arcuate fibers and form medial lemniscus–> synapse in VPL–>axon to sensory cortex

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14
Q

Sympathetic Neurons lie where? Para?

A

sympathetic–>thoracic and lumbar regions;

para-cranial/sacral

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15
Q

Brain development begins when and what is first step?

A

Week 3 with formation of neural fold and neural crest cells

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16
Q

what turns into what turns into what?

A

prosencephalon–>telencephalon(cerebral hemispheres) + diencephalon(thalamus and hypo)

Mesencephalon–>mesencephalon–>midbrain

Rhombencephalon–>metencephalon (pons and cerebellum) + myelencephalon (medulla)

17
Q

Roughly describe Neurogenesis and Migration

A

Ventricular zone neuroepithelial cells–>neuroblasts and glioblasts migrate to final location and form adult structures

18
Q

Neuroblasts form?

A

all neurons in CNS

19
Q

Glioblasts form?

A

radial glial cells, astrocytes, oligodendrocytes, ependymocytes, tanycytes and choroid plexus cells

20
Q

Significance of radial glial cells?

A

guide wires for migration of neurons

21
Q

Microglia arise from what type of cells?

A

monocytes that invade CNS during 3rd week

22
Q

Alar Plate

A

dorsal to sulcus limitans, sensory

23
Q

Basal Plate

A

ventral to sulcus limitans, motor

24
Q

Anterior Neural Pore (2 things)

A

Anencephaly, Encephalocele

25
Q

Posterior Nerural Pore (3)?

A

Spina bifida, meningocele, myelomeningocele.

Take your damn folate

26
Q

failure of neural tube closure results in which protein leaking that can be tested in mother?

A

AFP

27
Q

Spina Bifida Occulta v Aperta

A

SPA is a huge sac

28
Q

Arnold Chiari Malformation

A

displacement of cerebellar tonsils below foramen magnum (Budd’s brother ripped through his magnum)