5. new genes – exon shuffling – protein domains

Question 1

Protein ‘domain’

Answer 1

functional component of protein

Question 2

‘EXON shuffling’

Answer 2

• Exon duplication
• Exon insertion
• Exon deletion
• Exon fusion
• Exon movement

Question 3

principle exon-shuffling

Answer 3

is a molecular mechanism for the formation of new genes. It is a process through which two or more exons from different genes can be brought together ectopically, or the same exon can be duplicated, to create a new exon-intron structure.

Question 4

Relationship between protein domain and exon?

Answer 4

One exon or a few code for a particular protein domain

Question 5

What observations have led to the exon shuffling theory?

Answer 5

recombination within introns could help assort exons independently and that repetitive segments in the middle of introns could create hotspots for recombination to shuffle the exonic sequences

Question 6

What’s the role of repetitive DNA in exon shuffling

Answer 6

repetitive segments in the middle of introns could create hotspots for recombination to shuffle the exonic sequences

Question 7

Why are DNA transposons less frequently involved in exon shuffling than retro-elements?

Answer 7

Because of the RNA that needs to be sanitized and that includes the exon