5- Nature and Nurture of Psychopathology Flashcards

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1
Q

What is temperament

A

Individual differences in emotion, activity level, and attention that are exhibited across context and present from infancy

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2
Q

Types of adoption designs testing nature vs nurture

A
  • Biological and adoptive parents and adoptees

- Adoptive vs. non-adoptive families

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3
Q

Types of twin designs testing nature vs nurture

A
  • MZ vs. DZ twins

- Twins reared apart and together

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4
Q

Adoption design limitations

A
  • Adoptees are not placed randomly into adoptive families, they tend to be chosen to provide environments that are low-risk
  • Adoption studies may not be generalisable to the population at large
  • Prenatal influences are not taken into account
  • Adoption (especially, adoption at birth) is an unusual event in itself
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5
Q

Adoption study for child temperament found

A

Higher correlation between adoptees and their biological parents than adoptive parents

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6
Q

Twin studies for child temperament found

A

Consistently found that MZ co-twins are more similar than DZ co-twins across a wide variety of temperament dimensions including: emotionality, activity, sociability, attention/persistence, etc

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7
Q

Twin design limitations

A
  • Assumption that environments are similar for identical and fraternal twins, monozygotic twins share more similar environments -both prenatal and postnatal
  • Twin studies may not be generalisable to the population at large, eg twins are more susceptible to prenatal trauma leading to mental retardation
  • MZ twins may not be 100% genetically identical, there are various biological mechanisms that can lead to genetic differences between MZ twins
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8
Q

What is heritability

A
  • The proportion of variance in a population attributable to genetic differences between people
  • It’s a statistical estimate for a population (not an individual) studied
  • It does not refer to particular genes
  • Estimate applies only to a particular population living in a particular environment at a particular time
  • Estimate does not account for a complex interplay between genetic an environment factors
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9
Q

Twin study of child temperament

Lemery-Chalfantet al, 2013

A
  • 807 pairs of twins, mean age 8 years (301 MZ; 263 same-sex DZ; 243 opposite-sex DZ) from Wisconsin Twin Project
  • Parent telephone interviews, home visits
  • Finding 1: effortful control, negative affectivity, extraversion show high heritability: 54%, 79%, 49%
  • Finding 2: Home environments (how chaotic and unsafe they are) are also under genetic influence (heritable) and affect personality (extraversion)
  • Conclusion: Parents’ temperament can influence child temperament through genetic transmission and through home environment that they create
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10
Q

Developmental psychopathology uses what two approaches

A
  • Clinical diagnostic approach

- Empirical quantitative approach

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11
Q

What is the clinical diagnostic approach

A

Psychopathologies are considered to be discrete categories defined on the basis of criteria proposed by experts (DSM-IV; ICD-10)

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12
Q

What is the empirical quantitative approach

A

Psychopathology symptoms are assessed on a continuous scale, with the disorders being the extreme ends of the distribution

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13
Q

What are examples of Internalising psychopathology

A

Depression, Anxiety

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14
Q

What are examples of Externalising psychopathology:

A

Conduct problems, ADHD (attention problems, impulsivity)

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15
Q

Facts about psychopathology in children and youth

A
  • Major public health issue
  • Very common: 10-25%
  • Have early onset: 75% before age 25
  • Are chronic: 22-46% (up to 60% in young people)
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16
Q

Reasons for the study Nature and Nurture of Developmental Psychopathology

A
  • Understanding the origins and course of psychopathologies: diagnostic boundaries and overlap
  • Prediction: Identifying genetic variants that contributes to the risk of disorders
  • Treatment and prevention: Identifying genetic risk factors and biological mechanisms can inform new drug targets
  • Risk reduction interventions: Identifying environmental protective factors that modify genetic risk
17
Q

P = h2+ c2+ e2

A
  • P: Phenotypic variation
  • h2: Heritability
  • c2: Shared environment
  • e2: Non shared environment
18
Q

Heritability (A) equation

A

2(rMZ–rDZ)
rMZ: Identical twin resemblance
rDZ: Fraternal twin resemblance

19
Q

Shared Environment (C) equation

A

rMZ–h2

rMZ: Identical twin resemblance

20
Q

Non-Shared Environment (E) equation

A

1 –rMZ

rMZ: Identical twins resemblance

21
Q

Heritability of psychopathologies in children

A

ADHD: A = 90% (high)
Depression: A = 30% (moderate)

22
Q

What percentage of the DNA sequence is variable

A

1%

23
Q

Psychopathologies are influenced by

A

More than one genetic variant (polygenic traits)

24
Q

The hallmark of polygenic traits are

A
  • A bell curve distribution

- A continuous distribution

25
Q

More specific genetic variants (alleles) are

A

Higher risk of psychopathology