#5: Intro to Neuro Disorders

Question 1

Mc degenerative disorder of the motor neuron system

Answer 1

ALS

Question 2

Huntington’s chorea treatment:

Answer 2

• purely SXS tx; dz progression cannot be halted
• Haldol- behavior tx
• Reserpine- dyskinesia tx

Question 3

This drug is proven to prolong tracheostomy free survival by 2-3 months w/ ALS?

Answer 3

Riluzole (Rilutek)

Question 4

2 drugs recommended for SXS tx w/ ALS?

Answer 4

• Baclofen (Lioresal)

- Tizanidine (Zanaflex)

Question 5

Best predictor of prognosis for ALS:

Answer 5

rate of dz progression

Question 6

Median survival for ALS:

Answer 6

3 yrs from clinically apparent dz

– ALS is fatal

Question 7

Pharmological tx in CRPS and the drug SXS or targets: (4)

Answer 7

1- Prednisone: Q30-40 mg QD and tapered over 2-4 wks for mobility, pain and stiffness
2- IV Calcitonin for decreasing inflammation
3- NSAIDs for SXS relief
4- Sympathetic blockade: lidocaine or bupivicaine (+/- epinephrine): blocks the efferent SNS impulses from the affected limb; may cause I/L Horner’s syndrome

Question 8

Best prognosis w/ CRPS is when:

Answer 8

• detected and appropriately cared for early in the dz course (MC w/ children)

Question 9

List the medications may cause peripheral neuropathy: (4 major groups)

Answer 9

CASP

• MC* w/ Chemo drugs- vincristine, cisplatin, taxol
• Abx- metronidazole, isoniazid, linezolid (>21 days), fluoroquinolone, nitrofurantoin
• Statins
• Phenytoin

Question 10

Initial study of choice w. peripheral neuropathy:

Answer 10

EMG/NCS

if + then rq bx and directed lab eval

Question 11

MC inherited neuro disorder causing neuropathy w/o any metabolic cause:

Answer 11

Charcot-Marie-Tooth Dz (CMT)

Question 12

CMT its typically present w/:

Answer 12

SXS begin in the first 20 years of life w/ tripping over feet, increased falls, and clumsiness