5. Extracellular matrices Flashcards
What are the components of a tissue?
Cells + Matrix.
What are CELL JUNCTIONS?
Cell-cell and cell-matrix adhesions.
What is the BASAL LAMINA?
What is the EXTRACELLULAR MATRIX?
Network determining physical properties of connective tissues.
What properties of the cell does the ECM influence?
- Shape.
- Structure.
- Migration.
- Proliferation.
- Behavior.
- Development.
- Function!
What does DYNAMIC RECIPROCITY describe?
Relationship between the cell and it’s matrix.
What controls ECM organization?
Cytoskeletal orientation.
What is a FIBROBLAST?
Cell in connective tissue which produces collagen and other fibres.
Why are FIBROBLASTS often used as a model cell?
They can become other cell types + they are easy to maintain.
What effect does MATRIX ELASTICITY have on a cell?
It influences cell lineage.
What is CONNECTIVE TISSUE?
Tissue that supports, connects or separates different tissues or organs.
What components make up the EXTRACELLULAR MATRIX?
- Polysacharides.
- Proteins.
What are GLYCOSAMINOGLYCANS?
Long unbranched polysaccharides containing a repeating disaccharide unit.
What does ELASTIC MODULUS mean?
Describes the elastic properties of objects when they are stretched or compressed.
What is the ECM made of?
- Glycosaminoglycans.
- Fibrous proteins.
