5: cell membrane Flashcards
plasma membrane consits of
phospholipids, cholestrol and proteins
Phospholipids are the basic structure of the membrane, cholesterol is inserted between
lipid bilayer
polar head and non polar tail
integral protein
pore channels or carriers
3 passive transport
diffusion through lipid
diffusion through ion channel
diffusion using carrier
diffusion through lipid bilayer
lipid soluble substances
driving force for transport
diffusion across lipid layer
water-soluble substances (ions, amino acis, sugar, water)
small ions and water-> channels
sugar and amino acids -> facilitated diffusion
electrochemical gradient
facilitated diffusion
solute binds to the transporter on one side of the membrane and is realised on the other side
gated diffusion
some proteins are ion channels
electrochemical gradient driving force
ion channels are continuously open while some are open transiently
much faster than facilitated diffusion
active transport
requires energy-moving solutes against a concentration gradient
primary = energy directly from ATP
secondary = energy delivered indirectly from ATP
primary active transport
sodium and potassium pump
inside the cell there’s a low conc of Na+ ions and outside too much K+ ions
the pump then puts 3 Na+ from outside to inside and 2 K+ from inside to outside
secondary active transport
deriving other substances against their own concentration gradient
sodium ion gated, plasma membrane
exocytosis
movement of large molecules outside the cell (secretory cells)
- secretory vesicle moved down towards the plasma membrane
- secretory vesicle fuses with plasma membrane
- secretory vesicle content is released into the extracellular fluid
endocytosis
moving larger molecules and particles into the cell
- receptor molecules on cell surface bind to molecules to be taken into the cell
- receptors and the bound molecules taken into cell forming vesicle
- vesicle fuses and separates from plasma membrane
pinocytosis
emulsifying small particles and fluid
phagocytosis
emulsifying large particless
osmosis
movement of water molecules from a low solute concentration to a high solute concentration
across semi permeable membrane
water moves to solution with highest osmotic pressure
tonicity
solution’s ability to change the volume of cells by altering water content
isotonic solution
no net movement, cell miantain shape
hypotonic solution
cells gain water
swelling or bursting
hypertonic solution
cells loose water
becoming dehydrated and shrink
metabolism
all chemical reactions in body
catabolism
chemical reactions break complex organic molecules
anabolism
chemical reactions build up simple molecules in complex molecules
atp uses
muscle contraction, active transport, movement of structure within cell
energy generation
- large molecules broken down into smaller units
proteins -> peptides and amino acids
fats -> glyceral and fatty acids - smaller units degerated to a few simple key coumpinfs playing central role in metabolism
- krebs cyrcle or oxidative phosphorylation
glucose catabolised in 3 ways
krebs cycle
glycolysis
electron trasnport support chain
oxidative phosphorylation
cellular respiration the two types
anaerobic
-> atp production without o2
glycolysis
aerobic
-> atp production with O2
oxidative phosphorylation
4 steps
- glycolysis
- formation of acetly CoA
- Krebs cycle
- electron transport chain
glycolysis final product
2 pyruvic acid molecules
2NADH + H+ moleculesa
2 ATP molecules
If o2 avaliable: pyvloric acid prepares for krebs cycle in mitocondira
if no o2 PA accepts H2 from NADH2 forming lactic acid, diffusion out of the cell into bloodstream then liver cells remove lactic acid from the blood changing back to pyruvic acid
krebs cycle
pyloric acid enter mitochondria and undergoes decarboxylation removing CO2
2 acetyl group attach to coenzyme A
occurring in matrix of mitocondria
H+ -> sent to electron transport chain
NADH2 and FADH2 -> converted into energy
reaction occurring in matric of mitocondira
acetyl CoA eneter cycel combining with 4C to form citric acid
formation of citric acid
sum of krebs cycle
aceytl coA molecule enter krebs cycle forming
2 CO2
1 ATP
3 NADH2
1 FADH2
1 glucose 2 acetly coA molecules
electron transport chain
integral membrane proteins form a chain, located in the inner mitochondrial membrane
cytochrome picks up 1 electron passing onto next chain
small amounts of energy release in form at ATP