5. Catecholamine Metabolism

Question 1

Clorgiline

Answer 1

MAO-A specific inhibitor
Inhibits metabolism of NA, ADr, Dopamine and 5-HT
Used in depression

Question 2

Selegiline

Answer 2

MAO-B specific inhibitor
Inhibits Dopamine metabolism
Used in treatment of parkinsons

Question 3

Tranylcypromine

Answer 3

Non-selective irreversible MAO inhibitor used in the treatment of refractory depression

Question 4

Entacapone

Answer 4

Inhibitor of COMT (methylates hydroxyls in catecholamines/deaminated metabolites)
COMT is found in the liver & neuronal + non-neuronal tissues, associated with uptake 2
Used in parkinson’s disease