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Small Animal Flash cards > 44. Diseases Of The Neuromuscular Junction, Toicosis, Tetanus, Botulism > Flashcards

44. Diseases Of The Neuromuscular Junction, Toicosis, Tetanus, Botulism Flashcards

1
Q

Nmj

A

Axon terminal
Synaptic cleft
Endplate

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2
Q

General cs of nmj diseases

A 
Decr. Muscle tone 
Decr. Segmented spinal reflexes 
Cranial nerve deficits 
Tertaplegia 
Weakness
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3
Q

Pre synaptic

A

Less ach released from terminal
Lmn type deficits/cs
Hypotonia
Hyporeflexia

Eg. Botuilism

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4
Q

Post synaptic

A

Problems with Ach specifically
Exercise induced

Eg myasthenia gravis

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5
Q

Myasthenia gravis

A

Acquired vs congenital form

Acquired- autoantibodies produced against Ach receptors- Decr.no of functional recepetors

Congenital- Ach receptor deficiency/ abnormality on post synaptic

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6
Q

Myasthenia gravis 2

A

Forms
Generalized- normal at rest, exercise induced weakness- pareis, megaoesophagus

Focal - weakness of isolated muscle group

Fulminant - progressive symptoms

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