44. Diseases Of The Neuromuscular Junction, Toicosis, Tetanus, Botulism Flashcards
1
Q
Nmj
A
Axon terminal
Synaptic cleft
Endplate
2
Q
General cs of nmj diseases
A
Decr. Muscle tone Decr. Segmented spinal reflexes Cranial nerve deficits Tertaplegia Weakness
3
Q
Pre synaptic
A
Less ach released from terminal
Lmn type deficits/cs
Hypotonia
Hyporeflexia
Eg. Botuilism
4
Q
Post synaptic
A
Problems with Ach specifically
Exercise induced
Eg myasthenia gravis
5
Q
Myasthenia gravis
A
Acquired vs congenital form
Acquired- autoantibodies produced against Ach receptors- Decr.no of functional recepetors
Congenital- Ach receptor deficiency/ abnormality on post synaptic
6
Q
Myasthenia gravis 2
A
Forms
Generalized- normal at rest, exercise induced weakness- pareis, megaoesophagus
Focal - weakness of isolated muscle group
Fulminant - progressive symptoms